Synthesis and antimicrobial spectrum of FCE 22101 and its orally available ester FCE 22891

The most efficient routes for the synthesis of FCE 22101, a pencm antibiotic characterized by a carbamoyloxymethyl sidechain at C-2 identical to that of cefuroxime and cefotaxime, and of FCE 22891, its orally absorbed pro-drug, are described. On the basis of in-vitro antimicrobial profile and other...

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Bibliographic Details
Published in:Journal of antimicrobial chemotherapy 1989, Vol.23 (suppl-C), p.1-6
Main Authors: Franceschi, G., Perrone, E., Alpegiani, M., Bedeschi, A., Battistini, C., Zarini, F., Bruna, C. Della
Format: Article
Language:English
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Summary:The most efficient routes for the synthesis of FCE 22101, a pencm antibiotic characterized by a carbamoyloxymethyl sidechain at C-2 identical to that of cefuroxime and cefotaxime, and of FCE 22891, its orally absorbed pro-drug, are described. On the basis of in-vitro antimicrobial profile and other characteristics the compounds have been considered worthy of further development.
ISSN:0305-7453
1460-2091
DOI:10.1093/jac/23.suppl_C.1