Synthesis and antimicrobial spectrum of FCE 22101 and its orally available ester FCE 22891
The most efficient routes for the synthesis of FCE 22101, a pencm antibiotic characterized by a carbamoyloxymethyl sidechain at C-2 identical to that of cefuroxime and cefotaxime, and of FCE 22891, its orally absorbed pro-drug, are described. On the basis of in-vitro antimicrobial profile and other...
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Published in: | Journal of antimicrobial chemotherapy 1989, Vol.23 (suppl-C), p.1-6 |
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Main Authors: | , , , , , , |
Format: | Article |
Language: | English |
Subjects: | |
Citations: | Items that cite this one |
Online Access: | Get full text |
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Summary: | The most efficient routes for the synthesis of FCE 22101, a pencm antibiotic characterized by a carbamoyloxymethyl sidechain at C-2 identical to that of cefuroxime and cefotaxime, and of FCE 22891, its orally absorbed pro-drug, are described. On the basis of in-vitro antimicrobial profile and other characteristics the compounds have been considered worthy of further development. |
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ISSN: | 0305-7453 1460-2091 |
DOI: | 10.1093/jac/23.suppl_C.1 |