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Angiotensin I Converting Enzyme Gene Polymorphism in Chinese Patients With Hypertension

Reports from different ethnic populations failed to show consistent findings on the association of hypertension with insertion/deletion (I/D) polymorphism of the angiotensin I converting enzyme (ACE) gene. In this population association study in Chinese, we compared the distribution of the ACE genot...

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Bibliographic Details
Published in:American journal of hypertension 1997-05, Vol.10 (5), p.558-561
Main Authors: Jeng, Jing-Ren, Harn, Horng-Jyh, Jeng, Chii-Yuan, Yueh, Kuo-Cheu, Shieh, Shyh-Ming
Format: Article
Language:English
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Summary:Reports from different ethnic populations failed to show consistent findings on the association of hypertension with insertion/deletion (I/D) polymorphism of the angiotensin I converting enzyme (ACE) gene. In this population association study in Chinese, we compared the distribution of the ACE genotypes and allele frequency in 150 healthy controls with normal blood pressure and 148 hypertensive patients categorized by age. Although the frequencies of homozygote deletion (DD) genotype and deletion allele were greater in Chinese with hypertension than in normotensive controls (0.23 vs 0.13 and 0.44 v 0.37, respectively), the differences were not significant by χ 2 analysis ( P = .07 and .09, respectively). Furthermore, we did not find the trend of decreasing number of DD genotype in older hypertensive Chinese patients. The results indicated a much lower prevalence of ACE/DD genotype in Chinese than in Caucasians and a modest association between I/D polymorphism of the ACE gene and hypertension in Chinese.
ISSN:0895-7061
1879-1905
1941-7225
DOI:10.1016/S0895-7061(97)00036-8