Comparison of fast atom bombardment mass spectrometry and thermal ionization quadrupole mass spectrometry for the measurement of zinc absorption in human nutrition studies

A method is described for the measurement of apparent zinc absorption in human nutrition studies. An enriched source of the stable isotope 67Zn was given to adult subjects together with a wheat cereal and the unabsorbed 67Zn measured in the feces. After drying, subsamples of the homogenized fecal ma...

Full description

Saved in:
Bibliographic Details
Published in:Analytical chemistry (Washington) 1989-05, Vol.61 (9), p.1023-1025
Main Authors: Eagles, John, Fairweather-Tait, Susan J, Portwood, David E, Self, Ron, Goetz, Adolf, Heumann, Klaus G
Format: Article
Language:English
Subjects:
Biological and medical sciences
Biological Availability
Feeding. Feeding behavior
Fundamental and applied biological sciences. Psychology
Humans
Mass Spectrometry - methods
Nutritional Physiological Phenomena
Vertebrates: anatomy and physiology, studies on body, several organs or systems
Zinc - analysis
Zinc - pharmacokinetics
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:A method is described for the measurement of apparent zinc absorption in human nutrition studies. An enriched source of the stable isotope 67Zn was given to adult subjects together with a wheat cereal and the unabsorbed 67Zn measured in the feces. After drying, subsamples of the homogenized fecal material were ashed at 480 degrees C, purified for analysis by ion exchange chromatography, and the 64Zn/67Zn ratios determined by both fast atom bombardment mass spectrometry and thermal ionization quadrupole mass spectrometry. Good agreement was found between the two sets of results with mean precisions of approximately 0.5% for both techniques.
ISSN:0003-2700
1520-6882
DOI:10.1021/ac00184a021