Pathogenicity of Enterococci in a Rat Model of Fecal Peritonitis

The pathogenicity of enterococci in intraabdominal sepsis has not been clarified. Therefore, fecal-type peritonitis was induced in rats by intraperitoneal injection of barium sulfate along with a bacterial inoculum consisting of Escherichia coli, Bacteriodes fragilis, and Clostridium perfringens wit...

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Bibliographic Details
Published in:The Journal of infectious diseases 1989-07, Vol.160 (1), p.142-145
Main Authors: Matlow, Anne G., Bohnen, John M. A., Nohr, Carl, Christou, Nicholas, Meakins, Jonathon
Format: Article
Language:English
Subjects:
Abscess - microbiology
Abscesses
Animal models
Animals
Bacteria
Bacterial diseases
Bacteroides fragilis
Bacteroides Infections - complications
Biological and medical sciences
Clostridium Infections - complications
Clostridium perfringens
Concise Communications
Death
Enterococcus faecalis
Enterococcus faecalis - pathogenicity
Escherichia coli
Escherichia coli Infections - complications
Experimental bacterial diseases and models
Infectious diseases
Inoculum
Male
Medical sciences
Mortality
Peritonitis
Peritonitis - microbiology
Rats
Rats, Inbred Strains
Sepsis
Streptococcal Infections - complications
Streptococcal Infections - microbiology
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Summary:The pathogenicity of enterococci in intraabdominal sepsis has not been clarified. Therefore, fecal-type peritonitis was induced in rats by intraperitoneal injection of barium sulfate along with a bacterial inoculum consisting of Escherichia coli, Bacteriodes fragilis, and Clostridium perfringens with or without Streptococcus faecalis. Mortality at 19 d and characteristics of intraabdominal abscesses in survivors at 19 d were analyzed. The presence of S. faecalis in the original inoculum was significantly associated with death or large (>20 mm) abscess formation when these two end points were examined together. S. faecalis may synergize with other bacteria in intraabdominal sepsis to augment morbidity and possibly mortality.
ISSN:0022-1899
1537-6613
DOI:10.1093/infdis/160.1.142