Outcome and lineage involvement in t(12;21) childhood acute lymphoblastic leukaemia

The t(12;21)(p13;q22) translocation has been described recently as the most recurrent genetic lesion in paediatric acute lymphoblastic leukaemias (ALLs). It has also been associated with B‐precursor lineage involvement and good outcome. We tested 51 diagnostic paediatric ALLs and found 11 cases with...

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Bibliographic Details
Published in:British journal of haematology 1997-05, Vol.97 (2), p.460-462
Main Authors: Lanza, Carlo, Volpe, Gisella, Basso, Giuseppe, Gottardi, Enrico, Barisone, Elena, Spinelli, Monica, Ricotti, Emanuela, Cilli, Vania, Perfetto, Fatima, Madon, Enrico, Saglio, Giuseppe
Format: Article
Language:English
Subjects:
AML1
Biological and medical sciences
Cell Lineage
Child
Child, Preschool
childhood ALL
Chromosomes, Human, Pair 12
Chromosomes, Human, Pair 21
Female
Hematologic and hematopoietic diseases
Humans
Immunophenotyping
Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis
Male
Medical sciences
Phenotype
Polymerase Chain Reaction
Precursor Cell Lymphoblastic Leukemia-Lymphoma - genetics
Prognosis
TEL
Translocation, Genetic
translocations
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Summary:The t(12;21)(p13;q22) translocation has been described recently as the most recurrent genetic lesion in paediatric acute lymphoblastic leukaemias (ALLs). It has also been associated with B‐precursor lineage involvement and good outcome. We tested 51 diagnostic paediatric ALLs and found 11 cases with molecular evidence of the t(12;21). Interestingly, amongst t(12;21) positive patients, we report three cases with hybrid phenotype, and two cases showing an aggressive and fatal disease. Our data show that the t(12;21) does not represent an independent good‐risk indicator. Long follow‐ups and additional molecular investigations are needed to assess the prognostic and pathogenetic relevance of t(12;21) in childhood ALLs.
ISSN:0007-1048
1365-2141
DOI:10.1046/j.1365-2141.1997.312676.x