Usefulness of Signal-Averaged Electrocardiography in Evaluation of Idiopathic-Dilated Cardiomyopathy in Families

Family studies have confirmed that familial dilated cardiomyopathy is common and that a large proportion of relatives have mild left ventricular enlargement and therefore potentially early disease. Previous studies have shown that patients with idiopathic dilated cardiomyopathy have abnormalities of...

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Bibliographic Details
Published in:The American journal of cardiology 1997-05, Vol.79 (9), p.1203-1207
Main Authors: Yi, MD, Gang, Keeling, MD, Philip J, Hnatkova, PhD, Katerina, Goldman, MD, Jonathan H, Malik, PhD, MD, Marek, McKenna, MD, William J
Format: Article
Language:English
Subjects:
Adult
Aged
Biological and medical sciences
Cardiology. Vascular system
Cardiomyopathy, Dilated - diagnosis
Cardiomyopathy, Dilated - etiology
Cardiomyopathy, Dilated - prevention & control
Cardiovascular disease
Electrocardiography - methods
Families & family life
Family Health
Heart
Humans
Hypertrophy, Left Ventricular - complications
Male
Medical imaging
Medical sciences
Middle Aged
Myocarditis. Cardiomyopathies
Predictive Value of Tests
Prospective Studies
Risk Factors
Signal Processing, Computer-Assisted
Statistics, Nonparametric
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Summary:Family studies have confirmed that familial dilated cardiomyopathy is common and that a large proportion of relatives have mild left ventricular enlargement and therefore potentially early disease. Previous studies have shown that patients with idiopathic dilated cardiomyopathy have abnormalities of the signal-averaged electrocardiogram (ECG). We assessed the usefulness of analysis of the signal-averaged ECG in the evaluation of familial dilated cardiomyopathy. Signal-averaged electrocardiographic recordings were obtained from 58 patients with idiopathic dilated cardiomyopathy, from 161 of their relatives (35 of whom had left ventricular enlargement), and from 59 healthy subjects. Signal-averaged ECGs were analyzed using both time domain and spectral turbulence analysis techniques. The time domain and spectral turbulence analysis variables were markedly abnormal in patients with idiopathic dilated cardiomyopathy compared with relatives considered normal and healthy controls (p
ISSN:0002-9149
1879-1913
DOI:10.1016/S0002-9149(97)00083-0