An energy sensor for control of energy intake

Control of energy intake, either in response to changes in the energy content of food or in energy expenditures and storage, is based on the detection of a feedback signal generated in the processing of metabolic fuels for energy. Evidence from studies of the fructose analogue, 2,5-AM, indicates a s...

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Bibliographic Details
Published in:Proceedings of the Nutrition Society 1997-03, Vol.56 (1A), p.41-50
Main Author: Friedman, Mark I.
Format: Article
Language:English
Subjects:
Animals
Eating - drug effects
Eating - physiology
Energy Intake - physiology
Humans
Liver - drug effects
Liver - metabolism
Liver - physiology
Mannitol - analogs & derivatives
Mannitol - pharmacology
Symposium on ‘Mechanisms of energy compensation’
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Summary:Control of energy intake, either in response to changes in the energy content of food or in energy expenditures and storage, is based on the detection of a feedback signal generated in the processing of metabolic fuels for energy. Evidence from studies of the fructose analogue, 2,5-AM, indicates a sensor in liver responds to changes in intracellular ATP or some closely associated event and communicates this information to the brain via vagal afferent neurons. Such a mechanism could serve as the energy sensor which controls energy intake.
ISSN:0029-6651
1475-2719
DOI:10.1079/PNS19970008