Salicylate-selective membrane electrode based on tin(IV)-tetraphenylporphyrin

The response properties of a new solvent/polymeric membrane electrode with unique selectivity toward anionic salicylate are reported. The electrode is prepared by incorporating 5, 10, 15, 20-tetraphenyl(porphyrinato)tin(IV) dichloride (Sn[TPP]Cl2) into a plasticized poly(vinyl chloride) membrane. Th...

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Bibliographic Details
Published in:Analytical chemistry (Washington) 1989-03, Vol.61 (6), p.566-570
Main Authors: Chaniotakis, N. A, Park, S. B, Meyerhoff, Mark E
Format: Article
Language:English
Subjects:
Chemistry
Electrochemistry
Electrodes
Electrodes: preparations and properties
Exact sciences and technology
General and physical chemistry
Hydrogen-Ion Concentration
Ion selective electrodes
Metalloporphyrins
Miscellaneous
Other electrodes
Salicylates - blood
Salicylates - metabolism
Salicylates - urine
Study of interfaces
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Summary:The response properties of a new solvent/polymeric membrane electrode with unique selectivity toward anionic salicylate are reported. The electrode is prepared by incorporating 5, 10, 15, 20-tetraphenyl(porphyrinato)tin(IV) dichloride (Sn[TPP]Cl2) into a plasticized poly(vinyl chloride) membrane. The resulting sensor exhibits an anti-Hofmeister selectivity pattern, with high specificity for salicylate over lipophilic inorganic anions (perchlorate, periodate, thiocyanate, iodide, etc.) and biological organic anions (citrate, lactate, acetate). Moderate selectivity over structural analogues of salicylate (3- and 4-hydroxybenzoate, benzoate) is also observed. Radiotracer uptake experiments using [14C]salicylate clearly show that the metal center of the metalloporphyrin is critical for selective salicylate transport in the membrane phase. Minimal response to chloride ions makes the new electrode potentially useful for estimating salicylate levels in biological samples.
ISSN:0003-2700
1520-6882
DOI:10.1021/ac00181a013