Acquired monosomy 7 in donor cells in a patient treated for acute lymphoblastic leukemia with bone marrow transplantation

• Published in: Cancer genetics and cytogenetics 1997-06, Vol.95 (2), p.190-197
• Main Authors: Shekhter-Levin, Sofia, Bloom, Elana J., Swerdlow, Steven H., Sherer, Maureen E., Wald, Niel, Gollin, Susanne M.
• Format: Article
• Language: English
• Subjects: Adult; Biological and medical sciences; Bone Marrow Transplantation; Chromosomes, Human, Pair 7; Female; Hematologic and hematopoietic diseases; Humans; Karyotyping; Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis; Male; Medical sciences; Monosomy; Precursor Cell Lymphoblastic Leukemia-Lymphoma - genetics; Precursor Cell Lymphoblastic Leukemia-Lymphoma - therapy
• ISSN: 0165-4608; 1873-4456
• DOI: 10.1016/S0165-4608(96)00263-4

Two years after a bone marrow transplant (BMT) from his haploidentical mother, a 28-year-old male with a history of acute lymphoblastic leukemia (ALL) developed myelodysplastic syndrome (MDS) with monosomy 7 in his female bone marrow cells. Follow-up cytogenetic studies, including fluorescence in situ hybridization (FISH) performed twenty-seven and thirty-one months post-BMT consistently showed a female chromosome pattern with monosomy 7. Thirty-six and thirty-nine months post-BMT, further clonal evolution occurred, with the appearance of a sideline of the female cells that first expressed a del(10)(p11.2) and then developed a translocation, t(10;21)(p11.2;q22), in addition to the monosomy 7. Cytogenetic monitoring of this male patient helped to reveal a rare case of early MDS in transplanted donor cells and evolution of the acquired abnormal clone by identifying chromosomal alterations in the donated female bone marrow cells.