Effects of rat galanin and galanin message associated peptide (GMAP) on rat growth hormone secretion and stimulating effect of γ-aminobutyric acid on galanin release from rat hypothalamus

Immunoreactive galanin and galanin message associated peptide (GMAP) were detectable in rat hypothalamus in the concentration of 563±23 and 14.3±3.1 fmol/hypothalamus, respectively. γ-Aminobutyric acid (GABA) elicited a dose-related increase in galanin release from rat hypothalamic fragments, which...

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Bibliographic Details
Published in:Neuroscience letters 1997-05, Vol.226 (3), p.199-202
Main Authors: Nishiki, Masateru, Murakami, Yoshio, Sohmiya, Motoi, Tanaka, Junko, Yamauchi, Katsumi, Koshimura, Kunio, Kato, Yuzuru
Format: Article
Language:English
Subjects:
Analysis of Variance
Animals
Biological and medical sciences
Fundamental and applied biological sciences. Psychology
GABA Antagonists - pharmacology
Galanin
Galanin - metabolism
Galanin - pharmacology
Galanin message associated peptide
gamma-Aminobutyric Acid - pharmacology
Growth hormone
Growth Hormone - metabolism
Hormones and neuropeptides. Regulation
Hypothalamus - drug effects
Hypothalamus - metabolism
Hypothalamus. Hypophysis. Epiphysis. Urophysis
Male
Peptide Fragments - pharmacology
Picrotoxin - pharmacology
Pituitary Gland, Anterior - drug effects
Pituitary Gland, Anterior - metabolism
Rat
Rats
Rats, Wistar
Stimulation, Chemical
Vertebrates: endocrinology
γ-Aminobutyric acid
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Summary:Immunoreactive galanin and galanin message associated peptide (GMAP) were detectable in rat hypothalamus in the concentration of 563±23 and 14.3±3.1 fmol/hypothalamus, respectively. γ-Aminobutyric acid (GABA) elicited a dose-related increase in galanin release from rat hypothalamic fragments, which was inhibited by picrotoxin, a GABA antagonist. Growth hormone (GH) secretion from rat anterior pituitary cells were stimulated by rat galanin, but not by GMAP. These findings suggest that hypothalamic galanin, but not GMAP, may play roles in GH secretion induced by GABAergic mechanisms in the rat.
ISSN:0304-3940
1872-7972
DOI:10.1016/S0304-3940(97)00277-2