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Effects of rat galanin and galanin message associated peptide (GMAP) on rat growth hormone secretion and stimulating effect of γ-aminobutyric acid on galanin release from rat hypothalamus
Immunoreactive galanin and galanin message associated peptide (GMAP) were detectable in rat hypothalamus in the concentration of 563±23 and 14.3±3.1 fmol/hypothalamus, respectively. γ-Aminobutyric acid (GABA) elicited a dose-related increase in galanin release from rat hypothalamic fragments, which...
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| Published in: | Neuroscience letters 1997-05, Vol.226 (3), p.199-202 |
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| Main Authors: | , , , , , , |
| Format: | Article |
| Language: | English |
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| cited_by | cdi_FETCH-LOGICAL-c352t-d0645c2adef02e4126f8dbdaa2b570cff98dcbc8a75f6d039d8e54c6f2b1813b3 |
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| cites | cdi_FETCH-LOGICAL-c352t-d0645c2adef02e4126f8dbdaa2b570cff98dcbc8a75f6d039d8e54c6f2b1813b3 |
| container_end_page | 202 |
| container_issue | 3 |
| container_start_page | 199 |
| container_title | Neuroscience letters |
| container_volume | 226 |
| creator | Nishiki, Masateru Murakami, Yoshio Sohmiya, Motoi Tanaka, Junko Yamauchi, Katsumi Koshimura, Kunio Kato, Yuzuru |
| description | Immunoreactive galanin and galanin message associated peptide (GMAP) were detectable in rat hypothalamus in the concentration of 563±23 and 14.3±3.1 fmol/hypothalamus, respectively.
γ-Aminobutyric acid (GABA) elicited a dose-related increase in galanin release from rat hypothalamic fragments, which was inhibited by picrotoxin, a GABA antagonist. Growth hormone (GH) secretion from rat anterior pituitary cells were stimulated by rat galanin, but not by GMAP. These findings suggest that hypothalamic galanin, but not GMAP, may play roles in GH secretion induced by GABAergic mechanisms in the rat. |
| doi_str_mv | 10.1016/S0304-3940(97)00277-2 |
| format | article |
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γ-Aminobutyric acid (GABA) elicited a dose-related increase in galanin release from rat hypothalamic fragments, which was inhibited by picrotoxin, a GABA antagonist. Growth hormone (GH) secretion from rat anterior pituitary cells were stimulated by rat galanin, but not by GMAP. These findings suggest that hypothalamic galanin, but not GMAP, may play roles in GH secretion induced by GABAergic mechanisms in the rat.</description><identifier>ISSN: 0304-3940</identifier><identifier>EISSN: 1872-7972</identifier><identifier>DOI: 10.1016/S0304-3940(97)00277-2</identifier><identifier>PMID: 9175601</identifier><identifier>CODEN: NELED5</identifier><language>eng</language><publisher>Shannon: Elsevier Ireland Ltd</publisher><subject>Analysis of Variance ; Animals ; Biological and medical sciences ; Fundamental and applied biological sciences. Psychology ; GABA Antagonists - pharmacology ; Galanin ; Galanin - metabolism ; Galanin - pharmacology ; Galanin message associated peptide ; gamma-Aminobutyric Acid - pharmacology ; Growth hormone ; Growth Hormone - metabolism ; Hormones and neuropeptides. Regulation ; Hypothalamus - drug effects ; Hypothalamus - metabolism ; Hypothalamus. Hypophysis. Epiphysis. Urophysis ; Male ; Peptide Fragments - pharmacology ; Picrotoxin - pharmacology ; Pituitary Gland, Anterior - drug effects ; Pituitary Gland, Anterior - metabolism ; Rat ; Rats ; Rats, Wistar ; Stimulation, Chemical ; Vertebrates: endocrinology ; γ-Aminobutyric acid</subject><ispartof>Neuroscience letters, 1997-05, Vol.226 (3), p.199-202</ispartof><rights>1997 Elsevier Science Ireland Ltd</rights><rights>1997 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c352t-d0645c2adef02e4126f8dbdaa2b570cff98dcbc8a75f6d039d8e54c6f2b1813b3</citedby><cites>FETCH-LOGICAL-c352t-d0645c2adef02e4126f8dbdaa2b570cff98dcbc8a75f6d039d8e54c6f2b1813b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2666330$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9175601$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Nishiki, Masateru</creatorcontrib><creatorcontrib>Murakami, Yoshio</creatorcontrib><creatorcontrib>Sohmiya, Motoi</creatorcontrib><creatorcontrib>Tanaka, Junko</creatorcontrib><creatorcontrib>Yamauchi, Katsumi</creatorcontrib><creatorcontrib>Koshimura, Kunio</creatorcontrib><creatorcontrib>Kato, Yuzuru</creatorcontrib><title>Effects of rat galanin and galanin message associated peptide (GMAP) on rat growth hormone secretion and stimulating effect of γ-aminobutyric acid on galanin release from rat hypothalamus</title><title>Neuroscience letters</title><addtitle>Neurosci Lett</addtitle><description>Immunoreactive galanin and galanin message associated peptide (GMAP) were detectable in rat hypothalamus in the concentration of 563±23 and 14.3±3.1 fmol/hypothalamus, respectively.
γ-Aminobutyric acid (GABA) elicited a dose-related increase in galanin release from rat hypothalamic fragments, which was inhibited by picrotoxin, a GABA antagonist. Growth hormone (GH) secretion from rat anterior pituitary cells were stimulated by rat galanin, but not by GMAP. These findings suggest that hypothalamic galanin, but not GMAP, may play roles in GH secretion induced by GABAergic mechanisms in the rat.</description><subject>Analysis of Variance</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>GABA Antagonists - pharmacology</subject><subject>Galanin</subject><subject>Galanin - metabolism</subject><subject>Galanin - pharmacology</subject><subject>Galanin message associated peptide</subject><subject>gamma-Aminobutyric Acid - pharmacology</subject><subject>Growth hormone</subject><subject>Growth Hormone - metabolism</subject><subject>Hormones and neuropeptides. Regulation</subject><subject>Hypothalamus - drug effects</subject><subject>Hypothalamus - metabolism</subject><subject>Hypothalamus. Hypophysis. Epiphysis. Urophysis</subject><subject>Male</subject><subject>Peptide Fragments - pharmacology</subject><subject>Picrotoxin - pharmacology</subject><subject>Pituitary Gland, Anterior - drug effects</subject><subject>Pituitary Gland, Anterior - metabolism</subject><subject>Rat</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Stimulation, Chemical</subject><subject>Vertebrates: endocrinology</subject><subject>γ-Aminobutyric acid</subject><issn>0304-3940</issn><issn>1872-7972</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1997</creationdate><recordtype>article</recordtype><recordid>eNqFkc1u1DAUhS0EKkPhESp5gVC7CPgnsZMVqqpSkIpAAtaWY1_PGCVxsB3QPBdbnoFnIpkMs-3Klu53zrm6B6ELSl5TQsWbL4STsuBNSS4beUUIk7Jgj9CG1pIVspHsMdqckKfoWUrfCSEVrcozdNZQWQlCN-jPrXNgcsLB4agz3upOD37AerCnfw8p6S1gnVIwXmeweIQxewv48u7j9ecrHIZVHMOvvMO7EPswAE5gImQfVreUfT91Ovthi-EQumT-_V3o3g-hnfI-eoO18Xax-58doQOdALsY-kPGbj-GvJun_ZSeoydOdwleHN9z9O3d7deb98X9p7sPN9f3heEVy4UloqwM0xYcYVBSJlxtW6s1aytJjHNNbU1rai0rJyzhja2hKo1wrKU15S0_R69W3zGGHxOkrHqfDHTzihCmpGRDuKhp-SBIBZeMMTKD1QqaGFKK4NQYfa_jXlGilnrVoV61dKcaqQ71KjbrLo4BU9uDPamOfc7zl8e5TkZ3LurB-HTCmBCC8yX-7YrBfLWfHqJKxsNgwPo4F6Ns8A8s8g_nE8Zd</recordid><startdate>19970502</startdate><enddate>19970502</enddate><creator>Nishiki, Masateru</creator><creator>Murakami, Yoshio</creator><creator>Sohmiya, Motoi</creator><creator>Tanaka, Junko</creator><creator>Yamauchi, Katsumi</creator><creator>Koshimura, Kunio</creator><creator>Kato, Yuzuru</creator><general>Elsevier Ireland Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>19970502</creationdate><title>Effects of rat galanin and galanin message associated peptide (GMAP) on rat growth hormone secretion and stimulating effect of γ-aminobutyric acid on galanin release from rat hypothalamus</title><author>Nishiki, Masateru ; Murakami, Yoshio ; Sohmiya, Motoi ; Tanaka, Junko ; Yamauchi, Katsumi ; Koshimura, Kunio ; Kato, Yuzuru</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c352t-d0645c2adef02e4126f8dbdaa2b570cff98dcbc8a75f6d039d8e54c6f2b1813b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1997</creationdate><topic>Analysis of Variance</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>GABA Antagonists - pharmacology</topic><topic>Galanin</topic><topic>Galanin - metabolism</topic><topic>Galanin - pharmacology</topic><topic>Galanin message associated peptide</topic><topic>gamma-Aminobutyric Acid - pharmacology</topic><topic>Growth hormone</topic><topic>Growth Hormone - metabolism</topic><topic>Hormones and neuropeptides. Regulation</topic><topic>Hypothalamus - drug effects</topic><topic>Hypothalamus - metabolism</topic><topic>Hypothalamus. Hypophysis. Epiphysis. Urophysis</topic><topic>Male</topic><topic>Peptide Fragments - pharmacology</topic><topic>Picrotoxin - pharmacology</topic><topic>Pituitary Gland, Anterior - drug effects</topic><topic>Pituitary Gland, Anterior - metabolism</topic><topic>Rat</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Stimulation, Chemical</topic><topic>Vertebrates: endocrinology</topic><topic>γ-Aminobutyric acid</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Nishiki, Masateru</creatorcontrib><creatorcontrib>Murakami, Yoshio</creatorcontrib><creatorcontrib>Sohmiya, Motoi</creatorcontrib><creatorcontrib>Tanaka, Junko</creatorcontrib><creatorcontrib>Yamauchi, Katsumi</creatorcontrib><creatorcontrib>Koshimura, Kunio</creatorcontrib><creatorcontrib>Kato, Yuzuru</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Neuroscience letters</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Nishiki, Masateru</au><au>Murakami, Yoshio</au><au>Sohmiya, Motoi</au><au>Tanaka, Junko</au><au>Yamauchi, Katsumi</au><au>Koshimura, Kunio</au><au>Kato, Yuzuru</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of rat galanin and galanin message associated peptide (GMAP) on rat growth hormone secretion and stimulating effect of γ-aminobutyric acid on galanin release from rat hypothalamus</atitle><jtitle>Neuroscience letters</jtitle><addtitle>Neurosci Lett</addtitle><date>1997-05-02</date><risdate>1997</risdate><volume>226</volume><issue>3</issue><spage>199</spage><epage>202</epage><pages>199-202</pages><issn>0304-3940</issn><eissn>1872-7972</eissn><coden>NELED5</coden><abstract>Immunoreactive galanin and galanin message associated peptide (GMAP) were detectable in rat hypothalamus in the concentration of 563±23 and 14.3±3.1 fmol/hypothalamus, respectively.
γ-Aminobutyric acid (GABA) elicited a dose-related increase in galanin release from rat hypothalamic fragments, which was inhibited by picrotoxin, a GABA antagonist. Growth hormone (GH) secretion from rat anterior pituitary cells were stimulated by rat galanin, but not by GMAP. These findings suggest that hypothalamic galanin, but not GMAP, may play roles in GH secretion induced by GABAergic mechanisms in the rat.</abstract><cop>Shannon</cop><pub>Elsevier Ireland Ltd</pub><pmid>9175601</pmid><doi>10.1016/S0304-3940(97)00277-2</doi><tpages>4</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0304-3940 |
| ispartof | Neuroscience letters, 1997-05, Vol.226 (3), p.199-202 |
| issn | 0304-3940 1872-7972 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_79036814 |
| source | ScienceDirect Journals |
| subjects | Analysis of Variance Animals Biological and medical sciences Fundamental and applied biological sciences. Psychology GABA Antagonists - pharmacology Galanin Galanin - metabolism Galanin - pharmacology Galanin message associated peptide gamma-Aminobutyric Acid - pharmacology Growth hormone Growth Hormone - metabolism Hormones and neuropeptides. Regulation Hypothalamus - drug effects Hypothalamus - metabolism Hypothalamus. Hypophysis. Epiphysis. Urophysis Male Peptide Fragments - pharmacology Picrotoxin - pharmacology Pituitary Gland, Anterior - drug effects Pituitary Gland, Anterior - metabolism Rat Rats Rats, Wistar Stimulation, Chemical Vertebrates: endocrinology γ-Aminobutyric acid |
| title | Effects of rat galanin and galanin message associated peptide (GMAP) on rat growth hormone secretion and stimulating effect of γ-aminobutyric acid on galanin release from rat hypothalamus |
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