Sex‐Linked differences in susceptibility of cynomolgus monkeys to type II collagen–induced arthritis. Evidence that epitope‐specific immune suppression is involved in the regulation of type II collagen autoantibody formation

To determine whether sex‐linked factors are important in the susceptibility and resistance of cynomolgus monkeys to type II collagen–induced arthritis, we immunized 5 males and 10 females with chick type II collagen (CII) and studied their clinical and immune responses. All 10 females developed over...

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Bibliographic Details
Published in:Arthritis and rheumatism 1989-06, Vol.32 (6), p.748-758
Main Authors: Terato, Kuniaki, Arai, Haruyoshi, Shimozuru, Yasunori, Fukuda, Taneo, Tanaka, Hiroshi, Watanabe, Hideto, Nagai, Yutaka, Fujimoto, Koji, Okubo, Fumio, Cho, Fumiaki, Honjo, Shigeo, Cremer, Michael A.
Format: Article
Language:English
Subjects:
Animals
Antibody Formation
Arthritis - immunology
Arthritis, Experimental - diagnostic imaging
Arthritis, Experimental - immunology
Arthritis, Experimental - pathology
Biological and medical sciences
Collagen - adverse effects
Collagen - immunology
Cyanogen Bromide - immunology
Disease Models, Animal
Diseases of the osteoarticular system
Epitopes
Female
Freund's Adjuvant
Inflammatory joint diseases
Kinetics
Macaca - immunology
Macaca fascicularis - immunology
Male
Medical sciences
Peptides - immunology
Radiography
Sex Factors
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Summary:To determine whether sex‐linked factors are important in the susceptibility and resistance of cynomolgus monkeys to type II collagen–induced arthritis, we immunized 5 males and 10 females with chick type II collagen (CII) and studied their clinical and immune responses. All 10 females developed overt arthritis and produced antibodies to CII and cross‐reactive antibodies to monkey type II collagen (MkII). In contrast, only 1 male monkey developed arthritis, which was transient and mild in severity. Examination of antisera obtained from the male monkeys disclosed high titers of antibody to CII, but little antibody to MkII. The cyanogen bromide peptide recognition patterns varied markedly from animal to animal, implying that monkeys are capable of recognizing multiple arthritogenic determinants on CII.
ISSN:0004-3591
1529-0131
DOI:10.1002/anr.1780320613