Follicular dendritic cells and presentation of antigen and costimulatory signals to B cells

This review focuses on how immunogens trapped by FDC In the form of Ag‐Ab complexes productively signal B cells. In vitro, Ag‐Ab complexes are poorly immunogenic but m vivo immune complexes elk ii potent recall responses. FDC trap Ag‐Ab complexes and make immune complex mated bodies or “iccosomes”....

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Bibliographic Details
Published in:Immunological reviews 1997-04, Vol.156 (1), p.39-52
Main Authors: Tew, John G., Wu, Jiuhua, Qin, Dahui, Helm, Shirley, Burton, Gregory F., Szakal, Andrus K.
Format: Article
Language:English
Subjects:
Animals
Antibody Formation
Antigen Presentation - immunology
B-Lymphocytes - cytology
B-Lymphocytes - immunology
Dendritic Cells - cytology
Dendritic Cells - immunology
Germinal Center
Humans
Lymph Nodes - cytology
Lymph Nodes - immunology
Models, Immunological
Signal Transduction
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Summary:This review focuses on how immunogens trapped by FDC In the form of Ag‐Ab complexes productively signal B cells. In vitro, Ag‐Ab complexes are poorly immunogenic but m vivo immune complexes elk ii potent recall responses. FDC trap Ag‐Ab complexes and make immune complex mated bodies or “iccosomes”. B cells endocytose iccosomes, the Ag is processed, and T‐cell help is elicited. In vitro, addition of FDC bearing appropriate Ag‐Ab complex to memory T and B cells provoke potent recall responses (IgG and IgE). FDC also provide nonspecific costimulatory signals which augment B‐cell proliferation and Ab production. B cell‐FDC contact is important and interference with ICAM‐1‐LFA‐1 interactions reduces FDC‐mediated costimulation. Preliminary data suggest that a costimulatory signal may be delivered via CRZL on FDC binding CR2 on B cells. FDC can also stimulate B cells to become chemotactically active and can protect lymphocytes from apoptosis. FDC also appear to be rich in that groups and may replace reducing compounds such as 2 mercaptoethanol in cultures. In short, FDC‐Ag specifically signals B cells through BCR, and FDC provide B cells with iccosomal‐Ag necessary for processing to elicit T i ell help. In addition, FDC provide nonspecific signals that are important to promote B‐cell proliferation, maintain viability, and induce chemotactic responsiveness.
ISSN:0105-2896
1600-065X
DOI:10.1111/j.1600-065X.1997.tb00957.x