Immunogenic and protective properties of haemagglutinin protein (H) of Rinderpest virus expressed by a recombinant baculovirus

The hemagglutinin (H) protein of Rinderpest virus expressed by a recombinant baculo-virus used as a vaccine produced high titres of neutralizing antibody to Rinderpest virus in the vaccinated cattle, comparable to the levels produced by live attenuated vaccine. The immunized cattle were protected ag...

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Bibliographic Details
Published in:Vaccine 1997-04, Vol.15 (6), p.603-607
Main Authors: Naik, Sangeeta, Renukaradhya, G.J., Rajasekhar, M., Shaila, M.S.
Format: Article
Language:English
Subjects:
Animals
Antibodies, Viral - blood
baculovirus
Biological and medical sciences
Cattle
Cercopithecus aethiops
Fundamental and applied biological sciences. Psychology
Genetic Vectors
haemagglutinin
Hemagglutinins, Viral - genetics
Hemagglutinins, Viral - immunology
Microbiology
Nucleopolyhedrovirus
protective immunity
recombinent baculovirus
Rinderpest virus
Rinderpest virus - immunology
Spodoptera - cytology
Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies
Vaccines, Attenuated - immunology
Vaccines, Synthetic - immunology
Vero Cells
Viral Vaccines - immunology
Virology
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Summary:The hemagglutinin (H) protein of Rinderpest virus expressed by a recombinant baculo-virus used as a vaccine produced high titres of neutralizing antibody to Rinderpest virus in the vaccinated cattle, comparable to the levels produced by live attenuated vaccine. The immunized cattle were protected against a vaccine-virus challenge, as demonstrated by the failure of development of antibodies to N protein of the vaccine virus. The lack of replication of vaccine virus in the immunized cattle indicated that they are capable of showing a protective response if challenged with a virulent virus.
ISSN:0264-410X
1873-2518
DOI:10.1016/S0264-410X(96)00244-7