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Antioxidant enzyme activities in heart and skeletal muscle of rats of different ages

The activity of antioxidant enzymes was measured in cardiac and skeletal muscle in rats aged either 4, 15, or 27 months. Generally, regardless of age, heart contains a greater content of these enzymes than skeletal muscle. Whereas skeletal muscle showed age-dependent increases in glutathione peroxid...

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Bibliographic Details
Published in:Experimental gerontology 1989, Vol.24 (3), p.211-218
Main Authors: Vertechy, Mario, Cooper, Michael B., Ghirardi, Orlando, Ramacci, M.Teresa
Format: Article
Language:English
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Summary:The activity of antioxidant enzymes was measured in cardiac and skeletal muscle in rats aged either 4, 15, or 27 months. Generally, regardless of age, heart contains a greater content of these enzymes than skeletal muscle. Whereas skeletal muscle showed age-dependent increases in glutathione peroxidase, glutathione reductase, and catalase activities, heart tissue showed increases in only the glutathione peroxidase activity. Neither tissue showed any significant age-dependent change in cytosolic or mitochondrial superoxide dismutase content or in cytochrome oxidase.
ISSN:0531-5565
1873-6815
DOI:10.1016/0531-5565(89)90012-0