(S)NO Signals: Translocation, Regulation, and a Consensus Motif

Nitric oxide (NO) is a signaling molecule that has captured our imagination. According to the common view, NO diffuses over a large sphere of influence, moving freely through membranes of target cells to raise levels of cGMP. In the brain, NO influences synaptic plasticity, apoptosis, neuronal devel...

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Bibliographic Details
Published in:Neuron (Cambridge, Mass.) Mass.), 1997-05, Vol.18 (5), p.691-696
Main Authors: Stamler, Jonathan S., Toone, Eric J., Lipton, Stuart A., Sucher, Nikolaus J.
Format: Article
Language:English
Subjects:
Animals
Consensus Sequence - physiology
Nerve Tissue Proteins - chemistry
Nerve Tissue Proteins - metabolism
Nitric Oxide - metabolism
Signal Transduction - physiology
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Summary:Nitric oxide (NO) is a signaling molecule that has captured our imagination. According to the common view, NO diffuses over a large sphere of influence, moving freely through membranes of target cells to raise levels of cGMP. In the brain, NO influences synaptic plasticity, apoptosis, neuronal development, and even complex behavioral responses. This image has been reinforced by observations in the cardiovascular and immune systems, for example, the relaxation of blood vessels by cGMP, and the killing of tumor cells and bacteria by the macrophage NO synthase (NOS).
ISSN:0896-6273
1097-4199
DOI:10.1016/S0896-6273(00)80310-4