Interleukin-10 downregulates the intracerebral immune response in chronic Toxoplasma encephalitis

The expression of the immunosuppressive cytokine interleukin (IL)-10 in the normal and Toxoplasma gondii-infected murine brain was analysed. Microglia/macrophages expressed IL-10 at the mRNA and protein level in the normal brain. In Toxoplasma encephalitis (TE), CD4 + and CD8 + T-cells also contribu...

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Bibliographic Details
Published in:Journal of neuroimmunology 1997-06, Vol.76 (1), p.167-176
Main Authors: Deckert-Schlüter, Martina, Buck, Christine, Weiner, Daniela, Kaefer, Nadja, Rang, Andrea, Hof, Herbert, Wiestler, Otmar D, Schlüter, Dirk
Format: Article
Language:English
Subjects:
Animals
Brain - immunology
Chronic Disease
Down-Regulation
Encephalitis
Encephalitis - immunology
Female
Interleukin-10
Interleukin-10 - physiology
Mice
Mice, Inbred BALB C
Toxoplasma gondii
Toxoplasmosis, Cerebral - immunology
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Summary:The expression of the immunosuppressive cytokine interleukin (IL)-10 in the normal and Toxoplasma gondii-infected murine brain was analysed. Microglia/macrophages expressed IL-10 at the mRNA and protein level in the normal brain. In Toxoplasma encephalitis (TE), CD4 + and CD8 + T-cells also contributed to the upregulated IL-10 production. Neutralization of endogenous IL-10 in chronic TE reduced the intracerebral parasitic load and increased the number of immune cells and the production of protective cytokines. These findings indicate that intracerebral expression of IL-10 interferes with the immune response in TE and may contribute to parasite persistence in the brain.
ISSN:0165-5728
1872-8421
DOI:10.1016/S0165-5728(97)00047-7