S-Adenosyl-L-Methionine Ameliorates Ischemic Brain Metabolism in Spontaneously Hypertensive Rats

Effects of S-adenosyl-L-methionine (SAM) on the metabolism in ischemic brain were investigated. The ischemic model employed was an incomplete cerebral ischemia of the spontaneously hypertensive rat (SHR) produced by the occlusion of both common carotid arteries. One hundred mg/kg of SAM was administ...

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Bibliographic Details
Published in:Japanese journal of pharmacology 1989, Vol.49(2), pp.173-179
Main Authors: KOZUKA, Masao, IWATA, Nobuyoshi
Format: Article
Language:English
Subjects:
Adenosine Triphosphate - analysis
Animals
Biological and medical sciences
Blood Glucose - analysis
Body Water - analysis
Brain - metabolism
Brain Chemistry - drug effects
Brain Ischemia - metabolism
Energy Metabolism - drug effects
gamma-Aminobutyric Acid - analysis
General and cellular metabolism. Vitamins
Glucose - analysis
Lactates - analysis
Male
Medical sciences
Pharmacology. Drug treatments
Phosphocreatine - analysis
Rats
Rats, Inbred SHR
S-Adenosylmethionine - pharmacology
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Summary:Effects of S-adenosyl-L-methionine (SAM) on the metabolism in ischemic brain were investigated. The ischemic model employed was an incomplete cerebral ischemia of the spontaneously hypertensive rat (SHR) produced by the occlusion of both common carotid arteries. One hundred mg/kg of SAM was administered (i.p.) 6 times from the beginning of occlusion at 30 min intervals. At 3 hr after the onset of occlusion, animals were killed by microwave irradiation and creatine phosphate (CrP), ATP, glucose, lactate and γ-aminobutyric acid (GABA) contents in the brain were measured. SAM significantly mitigated both the reductions in CrP, ATP and glucose levels and the increase in GABA level due to the cerebral ischemia. In another set of experiments with the same experimental schedule, water content in the brain was examined. SAM significantly suppressed the increase in water content due to the cerebral ischemia. These results indicate ameliorating effects of SAM on the metabolism in ischemic brain.
ISSN:0021-5198
1347-3506
DOI:10.1254/jjp.49.173