Changes in cerebral blood flow accompanied with reduction of blood pressure treatment in patients with hypertensive intracerebral hemorrhages

Blood pressure usually is reduced in patients with hypertensive intracerebral hemorrhage for the prevention of the expansion of the hematoma and recurrent hemorrhage in acute stage. However, disturbed autoregulation of cerebral circulation is expected, and decreased cerebral blood flow (CaF) caused...

Full description

Saved in:
Bibliographic Details
Published in:Neurological research (New York) 1997-04, Vol.19 (2), p.169-173
Main Authors: Kuroda, Kiyoshi, Kuwata, Noriyuki, Sato, Naoya, Funayama, Masayuki, Yabuta, Akinori, Taguchi, Souichi, Suzuki, Michiyasu, Takahashi, Akira, Ogawa, Akira
Format: Article
Language:English
Subjects:
Adult
Aged
Antihypertensive Agents - therapeutic use
Autoregulation
Blood Pressure
CaF
Cerebral Hemorrhage - etiology
Cerebral Hemorrhage - physiopathology
Cerebrovascular Circulation - drug effects
Diltiazem - therapeutic use
Hematoma - etiology
Hematoma - physiopathology
Humans
Hypertension - complications
Hypertension - drug therapy
Hypertension - physiopathology
Hypertensive intracerebral hemorrhage
Hypotensives
Middle Aged
Nitroglycerin - therapeutic use
Thalamic Diseases - etiology
Thalamic Diseases - physiopathology
Trimethaphan - therapeutic use
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Blood pressure usually is reduced in patients with hypertensive intracerebral hemorrhage for the prevention of the expansion of the hematoma and recurrent hemorrhage in acute stage. However, disturbed autoregulation of cerebral circulation is expected, and decreased cerebral blood flow (CaF) caused by excessive hypotension has been pointed out. There are different mechanisms of action in hypotensives, thereby the influence of hypotension on CaF in patients with the thalamic hemorrhage was investigated using nitroglycerin (TNG), diltiazem hydrochloride (OH) and trimethaphan camsilate (TC). Average CaF in . a hemisphere on the hematoma side, the hemisphere without hematoma, and around the hematoma showed a slight decline after administration of TNG or OH. However, caF declined morel after TC than OH. OH and TNG are preferable in descending order to control blood pressure of patients with intracerebral hemorrhage in the acute stages in view of a smaller decline in caF. [Neural Res 1997; 19: 169-173]
ISSN:0161-6412
1743-1328
DOI:10.1080/01616412.1997.11740792