Possible association of infertility with sperm-specific abnormality of CD46

Three infertile patients fulfilling normal or subnormal criteria on routine semen analysis showed abnormal sperm CD46 (membrane cofactor protein of complement) by SDS-PAGE/immunoblotting analysis using a panel of monoclonal antibodies. The sperm CD46 isoform has been reported to be associated with s...

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Bibliographic Details
Published in:Journal of reproductive immunology 1997-04, Vol.33 (1), p.83-88
Main Authors: Kitamura, Masaya, Matsumiya, Kiyomi, Yamanaka, Masaki, Takahara, Siroh, Hara, Tomoko, Matsumoto, Misako, Namiki, Mikio, Okuyama, Akihiko, Seya, Tsukasa
Format: Article
Language:English
Subjects:
Acrosome - immunology
Adult
Antigens, CD - analysis
Antigens, CD - genetics
CD46
Epitope Mapping
Female
Humans
Infertility
Infertility, Male - immunology
Infertility, Male - pathology
Male
Membrane Cofactor Protein
Membrane Glycoproteins - analysis
Membrane Glycoproteins - genetics
Sperm-egg interactions
Spermatozoa - chemistry
Spermatozoa - immunology
Spermatozoa - pathology
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Summary:Three infertile patients fulfilling normal or subnormal criteria on routine semen analysis showed abnormal sperm CD46 (membrane cofactor protein of complement) by SDS-PAGE/immunoblotting analysis using a panel of monoclonal antibodies. The sperm CD46 isoform has been reported to be associated with sperm-egg interaction. These three patients expressed normal CD46 isoforms on their lymphocytes and granulocytes. Sperm-specific abnormalities in these proteins thus parallel male infertility, suggesting a new category of infertility, probably due to aberrations in the molecules related to sperm-egg interaction.
ISSN:0165-0378
1872-7603
DOI:10.1016/S0165-0378(97)01017-6