Neuroprotective Effects of Acetyl- l-Carnitine After Stroke in Rats

Study objective: To test the hypothesis that acetyl- l-carnitine (ALCAR) promotes neurologic recovery from experimental focal cerebral ischemia (stroke) in rats. Methods: We conducted a prospective, randomized, blinded study in which adult male Sprague-Dawley rats were subjected to coagulative occlu...

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Bibliographic Details
Published in:Annals of emergency medicine 1997-06, Vol.29 (6), p.758-765
Main Authors: Lolic, Milena Miljkovic, Fiskum, Gary, Rosenthal, Robert E
Format: Article
Language:English
Subjects:
Acetylcarnitine - therapeutic use
Animals
Biological and medical sciences
Cerebral Infarction - drug therapy
Cerebral Infarction - pathology
Disease Models, Animal
Drug Evaluation, Preclinical
Male
Medical sciences
Neurologic Examination
Neuropharmacology
Neuroprotective agent
Nootropic Agents - therapeutic use
Pharmacology. Drug treatments
Prospective Studies
Random Allocation
Rats
Rats, Sprague-Dawley
Single-Blind Method
Weight Loss
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Summary:Study objective: To test the hypothesis that acetyl- l-carnitine (ALCAR) promotes neurologic recovery from experimental focal cerebral ischemia (stroke) in rats. Methods: We conducted a prospective, randomized, blinded study in which adult male Sprague-Dawley rats were subjected to coagulative occlusion of the distal right middle cerebral artery (MCA) and temporary occlusion of both common carotid arteries (CCAs) for 60 minutes. After the onset of ischemia each rat was given ALCAR (200 mg/kg) or a similar volume of drug vehicle. Neurologic evaluation was performed on postoperative days 1, 2, 3, and 7. Postoperative weight loss was measured at day 7. Infarct volume was measured in separate groups of rats at 24 hours. Results: Neurologic outcomes, as assessed with an 11-point neurologic deficit scoring system, were significantly improved in ALCAR-treated rats on days 1, 2, and 3 ( P
ISSN:0196-0644
1097-6760
DOI:10.1016/S0196-0644(97)70197-5