The locus coeruleus of the Japanese monkey ( Macaca fuscata) does not express μ-opioid receptor-like immunoreactivity

It is well known that locus coeruleus (LC) of the rat shows intense μ-opioid receptor-like immunoreactivity (MOR-LI). In the course of our study on the distribution of MOR-LI in the brain of the Japanese monkey ( Macaca fuscata), however, no MOR-LI was found in the LC although the distribution patte...

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Bibliographic Details
Published in:Brain research 1997-05, Vol.755 (2), p.326-330
Main Authors: Chen, Jun, Koyama, Natsu, Kaneko, Takeshi, Mizuno, Noboru
Format: Article
Language:English
Subjects:
Amino Acid Sequence
Animals
Enkephalin
Enkephalin, Methionine - analysis
Humans
Immunohistochemistry
Locus coeruleus
Locus Coeruleus - chemistry
Macaca
Macaca fuscata
Male
Molecular Sequence Data
Monkey
Morphine
Rats
Rats, Sprague-Dawley
Receptors, Opioid, mu - analysis
Sequence Homology, Amino Acid
Species Specificity
μ-Opioid receptor
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Summary:It is well known that locus coeruleus (LC) of the rat shows intense μ-opioid receptor-like immunoreactivity (MOR-LI). In the course of our study on the distribution of MOR-LI in the brain of the Japanese monkey ( Macaca fuscata), however, no MOR-LI was found in the LC although the distribution pattern of MOR-LI in other regions of the lower brainstem of the monkey was essentially the same as that observed in the rat. It was also found that immunoreactivity for Met-enkephalin, the most potent endogenous ligand for MOR, was intense in the rat LC, but very weak, if any, in the monkey LC. MOR may not be expressed in the monkey LC.
ISSN:0006-8993
1872-6240
DOI:10.1016/S0006-8993(97)00191-1