Immunity status against poliomyelitis in persons 13–14 years old living in Rome

The immunity against poliomyelitis in 1000 subjects 13–14 years old was evaluated. Neutralizing antibodies against poliovirus type 1, 2 and 3 were detected in 97.6%, 95.8% and 70% of samples, respectively. 3 1000 (0.3%) subjects were simultaneously seronegative to the three types. WHO does not sugge...

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Bibliographic Details
Published in:Vaccine 1997-04, Vol.15 (6), p.747-750
Main Authors: Mastroeni, I., Patti, A.M., Fabrizi, A., Santi, A.L., Marinaro Manduca, A., Vescia, N., Squarcione, S., Fara, G.M.
Format: Article
Language:English
Subjects:
Adolescent
Antibodies, Viral - blood
Biological and medical sciences
Epidemiology. Vaccinations
General aspects
Humans
Immunization, Secondary
Infectious diseases
International Units
Medical sciences
neutralizing antibodies
poliomyelitis
Poliomyelitis - immunology
Poliomyelitis - prevention & control
Poliovirus - immunology
Rome
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Summary:The immunity against poliomyelitis in 1000 subjects 13–14 years old was evaluated. Neutralizing antibodies against poliovirus type 1, 2 and 3 were detected in 97.6%, 95.8% and 70% of samples, respectively. 3 1000 (0.3%) subjects were simultaneously seronegative to the three types. WHO does not suggest a protective level of International Units (IU), but our data indicate that such level is 0.45 IU for polio type 1, 0.65 IU for the type 2 and 0.138 for the type 3. A booster dose of vaccine in adolescence to ensure personal and herd immunity is recommended.
ISSN:0264-410X
1873-2518
DOI:10.1016/S0264-410X(96)00208-3