Radioimmunoscintigraphy with melanoma-associated monoclonal antibody fragments in choroidal melanoma

A prospective pilot study on radioimmunoscintigraphy with monoclonal antibody fragments against cutaneous melanoma (MoAb 225.28S) was carried out in 17 patients with a clinical diagnosis of choroidal melanoma. Monoclonal antibodies against melanoma-associated antigen were labeled with 740 mBq 99mTc...

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Bibliographic Details
Published in:Graefe's archive for clinical and experimental ophthalmology 1989-01, Vol.227 (3), p.291-294
Main Authors: SCHALING, D. F, VAN KROONENBURGH, M. J. P. G, BORSJE, R. A, CAMPUS, J. A. J, KAKEBEEKE-KEMME, H. M, OOSTERHUIS, J. A, PAUWELS, E. K. J
Format: Article
Language:English
Subjects:
Adult
Aged
Antibodies, Monoclonal
Biological and medical sciences
Choroid Neoplasms - diagnostic imaging
Female
Humans
Hypersensitivity - immunology
Injections, Intravenous
Male
Medical sciences
Melanoma - diagnostic imaging
Middle Aged
Ophthalmology
Pilot Projects
Prospective Studies
Radionuclide Imaging
Skin Neoplasms - immunology
Skin Tests
Time Factors
Tumors and pseudotumors of the eye, orbit, eyelid, lacrimal apparatus
Whole-Body Counting
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Summary:A prospective pilot study on radioimmunoscintigraphy with monoclonal antibody fragments against cutaneous melanoma (MoAb 225.28S) was carried out in 17 patients with a clinical diagnosis of choroidal melanoma. Monoclonal antibodies against melanoma-associated antigen were labeled with 740 mBq 99mTc and injected IV; images were made with a gamma camera at 6 h after injection. With a double-pinhole collimator, radioactivity was counted thrice in both eyes at 6 h after injection. In 6 of 16 patients (37.5%), the melanoma could be imaged with the gamma camera. With the double-pinhole collimator, a significantly higher activity was measured in the melanomatous eye in 13 of 16 patients (82.4%). In two patients a false negative result was obtained, and in one patient the difference between the left and right eye was not significant. Considering these results, radioimmunoscintigraphy may be valuable in ocular melanoma diagnostics, but the specificity of MoAb 225.28S needs to be assessed.
ISSN:0721-832X
1435-702X
DOI:10.1007/BF02172765