The role of ubiquinones in the regulation of lipid metabolism in rat thymocytes

The effect of ubiquinones Q-1, Q-2, Q-8 and Q-9 on lipid metabolism in rat thymocytes in vitro was studied. The cells were incubated in a medium containing ubiquinones within the concentration range from 1 to 1OOμM. A 2-fold decreased cholesterol synthesis was observed in thymocytes incubated with u...

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Bibliographic Details
Published in:FEBS letters 1989-06, Vol.249 (2), p.371-374
Main Author: Novoselova, E.G.
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
Cell metabolism, cell oxidation
Cell physiology
Cholesterol
Cholesterol - biosynthesis
Fundamental and applied biological sciences. Psychology
In Vitro Techniques
Lipid Metabolism
Male
Molecular and cellular biology
Rats
Rats, Inbred Strains
Thymocyte
Thymus Gland - drug effects
Thymus Gland - metabolism
Ubiquinone
Ubiquinone - pharmacology
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Summary:The effect of ubiquinones Q-1, Q-2, Q-8 and Q-9 on lipid metabolism in rat thymocytes in vitro was studied. The cells were incubated in a medium containing ubiquinones within the concentration range from 1 to 1OOμM. A 2-fold decreased cholesterol synthesis was observed in thymocytes incubated with ubiquinone Q-9 at a concentration of exogenous ubiquinone of no less than 40 μM. Incubation of thymocytes with ubiquinones UQ-1 and UQ-2 that are characteristic of rats (40 μM and 100 μM) resulted in a decrease of cholesterol synthesis. Ubiquinone-8 had a tendency to inhibit the cholesterogenesis in rat thymocytes.
ISSN:0014-5793
1873-3468
DOI:10.1016/0014-5793(89)80661-1