Comparison of the effect of two low-density lipoprotein receptor class mutations on coronary heart disease among French-Canadian patients heterozygous for familial hypercholesterolaemia

• Published in: European journal of clinical investigation 1997-05, Vol.27 (5), p.366-373
• Main Authors: VOHL, M.-C., GAUDET, D., MOORJANI, S., TREMBLAY, G., PERRON, P., GAGNÉ, C., LESIÈGE, D., BERGERON, J., LUPIEN, P. J., DESPRÉS, J-P.
• Format: Article
• Language: English
• Subjects: Adult; Aging; Angioplasty, Balloon, Coronary; Biological and medical sciences; Body Constitution; Body Mass Index; Cardiology. Vascular system; Coronary Angiography; Coronary Artery Bypass; Coronary artery disease; Coronary Disease - genetics; Coronary heart disease; familial hypercholesterolaemia; Female; Heart; Heterozygote; Humans; Hyperlipoproteinemia Type II - genetics; LDL-receptor gene mutations; Lipoprotein(a) - blood; Male; Medical sciences; Middle Aged; Mutation; Quebec; Receptors, LDL - genetics; Receptors, LDL - physiology
• ISSN: 0014-2972; 1365-2362
• DOI: 10.1046/j.1365-2362.1997.1250669.x

The aim of this study was to compare the age at first elective coronary angiogram and the age at first revascularization (coronary artery bypass grafting or percutaneous transluminal coronary angioplasty) in 102 patients without familial hypercholesterolaemia (FH), who were matched for age and sex with 76 heterozygous FH patients carrying a defective allele at the low‐density lipoprotein (LDL) receptor gene (LDL‐R) and 26 heterozygous FH patients bearing a null mutation at the LDL‐R. The prevalence of diabetes was significantly higher in the non‐FH group than in the two FH groups (P