Demonstration of the high‐affinity IgE receptor (FcɛRI) on Langerhans' cells of diseased nasal mucosa

• Published in: Allergy (Copenhagen) 1997-04, Vol.52 (4), p.436-439
• Main Authors: Haas, N., Hamann, K., Grabbe, J., Niehus, J., Kunkel, G., Kolde, G., Czarnetzki, B. M.
• Format: Article
• Language: English
• Subjects: Allergic diseases; Biological and medical sciences; Biopsy; Case-Control Studies; FcɛRI; FcɛRII; Humans; Hyperplasia; hyperplastic nasal conchae; Hypersensitivity, Immediate - immunology; Hypersensitivity, Immediate - surgery; Immunopathology; Langerhans Cells - immunology; mast cells; Medical sciences; nasal mucosa; Nasal Mucosa - immunology; Nasal Mucosa - pathology; nasal polyps; Nasal Polyps - immunology; Nasal Polyps - surgery; Nasal Provocation Tests; Receptors, IgE - immunology; Respiratory and ent allergic diseases; Rhinitis - immunology; Rhinitis - surgery; tangerhans' cells
• ISSN: 0105-4538; 1398-9995
• DOI: 10.1111/j.1398-9995.1997.tb01025.x

Haas N, Hamann K, Grabbe J, Niehus J, Kunkel G, Kolde G, Czarnetzki M. Demonstration of the high‐affinity IgE receptor (FcɛRI) on Langerhans' cells of diseased nasal mucosa. Langerhans' cells in the skin have recently been shown to bind IgE molecules via the high‐affinity IgE receptor (FcɛRI). Using two highly specific antibodies against the antibody‐binding α‐chain of this receptor, 29C6 and 6F7, we demonstrate by immunohistochemistry and immunoelectron microscopy that Langerhans' cells of diseased nasal mucosa can express the FcɛRI. Tissue sections from hyperplastic nasal conchae and nasal polyps of atopic and nonatopic patients have shown no basic differences in epithelial FcɛRII‐bearing cells. Only a few cells expressed the low‐affinity IgE receptor (FcɛRII) (Tül antibody) in some sections. These findings suggest that Langerhans' cells play an important role in the induction of transepithelial IgE‐mediated allergy and in the mediation of inflammation of the nasal mucosa via their FcɛRI.