Fluctuation of Zinc, Copper, Magnesium and Calcium Concentrations in Guinea Pig Tissues after Administration of Captopril (SQ 14225)

The effect of the administration of captopril on Zn (zinc), Cu (copper), Ca (calcium) and Mg (magnesium) concentrations in guinea pig tissues was studied. For nine weeks 2 mg captopril per kg b.w. were administered daily to adult male guinea pigs intraperitoneally. The concentrations of the studied...

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Bibliographic Details
Published in:Journal of trace elements in medicine and biology 1997-04, Vol.11 (1), p.32-36
Main Authors: Kotsaki-Kovatsi, V.-P., Koehler-Samouilidis, G., Kovatsis, A., Rozos, G.
Format: Article
Language:English
Subjects:
Adrenal Glands - drug effects
Adrenal Glands - metabolism
Animals
Antihypertensive agents
Biological and medical sciences
Calcium - metabolism
Calcium - urine
Captopril
Captopril - pharmacology
Cardiovascular system
Copper - metabolism
Copper - urine
Guinea Pigs
Hair - drug effects
Hair - metabolism
Jejunum - drug effects
Jejunum - metabolism
Liver - drug effects
Liver - metabolism
Magnesium - metabolism
Magnesium - urine
Male
Medical sciences
metal translocation
Organ Specificity
Pharmacology. Drug treatments
Reference Values
Zinc - metabolism
Zinc - urine
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Summary:The effect of the administration of captopril on Zn (zinc), Cu (copper), Ca (calcium) and Mg (magnesium) concentrations in guinea pig tissues was studied. For nine weeks 2 mg captopril per kg b.w. were administered daily to adult male guinea pigs intraperitoneally. The concentrations of the studied metals were determined in several tissues. Captopril significantly decreased Zn concentration in liver, Cu concentration in liver, adrenals, jejunum, urine and hair and Mg concentrations in blood and urine. A significant increase was observed in testicular and epididymal Zn, in heart, epididymal and fecal Cu, in Mg concentration of lung, kidney, adrenals, jejunum, epididymis and hair and in Ca concentrations in brain, heart, lung, kidney, spleen and stomach. No significant changes were observed in the colon and the thigh bone concentrations of the various elements tested. In conclusion Captopril treatment can produce translocation and/ or elimination of Zn, Cu, Mg and Ca ions in various tissues of guinea pigs.
ISSN:0946-672X
1878-3252
DOI:10.1016/S0946-672X(97)80007-7