Expression of a large family of POU-domain regulatory genes in mammalian brain development

A novel region referred to as the POU-domain is present in two tissue-specific transcription factors, Pit-1 and Oct-2, that activate expression of genes specifying pituitary and lymphocyte phenotypes. We report the identification of multiple new members of a large family of POU-domain genes expresse...

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Bibliographic Details
Published in:Nature (London) 1989-07, Vol.340 (6228), p.35-42
Main Authors: He, Xi, Treacy, Maurice N, Simmons, Donna M, Ingraham, Holly A, Swanson, Larry W, Rosenfeld, Michael G
Format: Article
Language:English
Subjects:
Amino Acid Sequence
Animals
Biological and medical sciences
Brain - embryology
Fundamental and applied biological sciences. Psychology
Gene expression
Gene Expression Regulation
Genes
Genes, Regulator
Genetics
Hormones
Humanities and Social Sciences
Humans
Lymphocytes
Mammals
Molecular and cellular biology
Molecular genetics
Molecular Sequence Data
multidisciplinary
Nervous system
Physical growth
Rats
Science
Science (multidisciplinary)
Sequence Homology, Nucleic Acid
Spinal Cord - embryology
Transcription Factors - genetics
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Summary:A novel region referred to as the POU-domain is present in two tissue-specific transcription factors, Pit-1 and Oct-2, that activate expression of genes specifying pituitary and lymphocyte phenotypes. We report the identification of multiple new members of a large family of POU-domain genes expressed in adult brain, and document that all the known mammalian POU-domain genes, including Pit-1 and Oct-2 , are expressed widely in the developing nervous system.
ISSN:0028-0836
1476-4687
DOI:10.1038/340035a0