Testosterone Replacement in Older Hypogonadal Men: A 12-Month Randomized Controlled Trial

A decline in testicular function is recognized as a common occurrence in older men. However data are sparse regarding the effects of hypogonadism on age-associated physical and cognitive declines. This study was undertaken to examine the year-long effects of testosterone administration in this patie...

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Bibliographic Details
Published in:The journal of clinical endocrinology and metabolism 1997-06, Vol.82 (6), p.1661-1667
Main Authors: Sih, Rahmawati, Morley, John E, Kaiser, Fran E, Perry, Horace M, Patrick, Ping, Ross, Candie
Format: Article
Language:English
Subjects:
Aged
Biological and medical sciences
Cognition - drug effects
Hand Strength
Hemoglobins - analysis
Hormones. Endocrine system
Humans
Hypogonadism - blood
Hypogonadism - drug therapy
Hypogonadism - immunology
Leptin
Male
Medical sciences
Middle Aged
Pharmacology. Drug treatments
Prostate-Specific Antigen - analysis
Proteins - analysis
Testosterone - therapeutic use
Time Factors
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Summary:A decline in testicular function is recognized as a common occurrence in older men. However data are sparse regarding the effects of hypogonadism on age-associated physical and cognitive declines. This study was undertaken to examine the year-long effects of testosterone administration in this patient population. Fifteen hypogonadal men (mean age 68 ± 6 yr) were randomly assigned to receive a placebo, and 17 hypogonadal men (mean age 65± 7 yr) were randomly assigned to receive testosterone. Hypogonadism was defined as a bioavailable testosterone
ISSN:0021-972X
1945-7197
DOI:10.1210/jcem.82.6.3988