Dopamine D1 and D2 antagonists block l-DOPA-induced air-stepping in decerebrate neonatal rats

l-DOPA administered to neonatal rats suspended in air elicits stereotypic locomotor activation termed air-stepping; it can be dose-dependently blocked by a dopamine (DA) D1 or D2 antagonist. In order to determine whether the forebrain is the site for this blockade, decerebrate 5-day-old rats were pr...

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Bibliographic Details
Published in:Brain research. Developmental brain research 1997-05, Vol.100 (1), p.130-132
Main Authors: McCrea, Anne E, Stehouwer, Donald J, Van Hartesveldt, Carol
Format: Article
Language:English
Subjects:
Air-stepping
Animals
Animals, Newborn
Benzazepines - pharmacology
Decerebrate
Decerebrate State
Development
Dopamine
Dopamine D2 Receptor Antagonists
Levodopa - antagonists & inhibitors
Levodopa - pharmacology
Locomotion
Motor Activity - drug effects
Rats
Receptors, Dopamine D1 - antagonists & inhibitors
SCH 23390
Spiperone
Spiperone - pharmacology
Stereotyped Behavior - drug effects
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Summary:l-DOPA administered to neonatal rats suspended in air elicits stereotypic locomotor activation termed air-stepping; it can be dose-dependently blocked by a dopamine (DA) D1 or D2 antagonist. In order to determine whether the forebrain is the site for this blockade, decerebrate 5-day-old rats were pretreated subcutaneously with either the DA D1 receptor antagonist SCH 23390 (16 mg/kg), the DA D2 receptor antagonist spiperone (6 mg/kg), or vehicle before receiving 100 mg/kg l-DOPA. Both antagonists blocked l-DOPA-induced air-stepping in both decerebrate and intact pups.
ISSN:0165-3806
DOI:10.1016/S0165-3806(97)00027-8