Participation of tenascin and transforming growth factor-β in reciprocal epithelial-mesenchymal interactions of MCF7 cells and fibroblasts

The tumor stroma is essential for the development of the tumor epithelium. Tenascin is an extracellular matrix protein highly expressed in the stroma of malignant mammary tumors. We therefore tested whether in vitro MCF7 cells were able to induce fibroblasts to synthesize tenascin. Indeed MCF7 cell-...

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Bibliographic Details
Published in:Cancer research (Chicago, Ill.) Ill.), 1989-08, Vol.49 (15), p.4322-4325
Main Authors: CHIQUET-EHRISMANN, R, KALLA, P, PEARSON, C. A
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
Breast Neoplasms - pathology
Cell Communication
Cell interactions, adhesion
Chick Embryo
Epithelium - pathology
Female
Fibroblasts - pathology
Fundamental and applied biological sciences. Psychology
Humans
Molecular and cellular biology
Proteins - physiology
Tenascin
Transforming Growth Factors - physiology
Tumor Cells, Cultured
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Summary:The tumor stroma is essential for the development of the tumor epithelium. Tenascin is an extracellular matrix protein highly expressed in the stroma of malignant mammary tumors. We therefore tested whether in vitro MCF7 cells were able to induce fibroblasts to synthesize tenascin. Indeed MCF7 cell-conditioned medium contained tenascin-inducing activity. This activity was shown to be transforming growth factor-beta. The morphology of the MCF7 cells was in turn affected by the addition of tenascin to the culture medium. The cells partially detached from the substratum and lost their cell-cell contracts.
ISSN:0008-5472
1538-7445