Respiratory-related pharyngeal constrictor muscle activity in normal human adults

• Published in: American journal of respiratory and critical care medicine 1997-06, Vol.155 (6), p.1991-1999
• Main Authors: KUNA, S. T, SMICKLEY, J. S, VANOYE, C. R
• Format: Article
• Language: English
• Subjects: Adult; Biological and medical sciences; Electromyography; Female; Fundamental and applied biological sciences. Psychology; General aspects; Humans; Hypercapnia - physiopathology; Hypocapnia - physiopathology; Hypoxia - physiopathology; Male; Muscle Contraction; Pharyngeal Muscles - physiology; Positive-Pressure Respiration; Pulmonary Ventilation; Reference Values; Respiration - physiology; Sleep - physiology; Sleep Stages - physiology; Vertebrates: respiratory system; Wakefulness - physiology; Work of Breathing
• ISSN: 1073-449X; 1535-4970
• DOI: 10.1164/ajrccm.155.6.9196107

Electromyographic activity of the superior, middle, and inferior pharyngeal constrictor (PC) muscles was examined in 10 normal adult humans during wakefulness and sleep. Wire electrodes were inserted close to the midline of the posterior pharyngeal wall at the level of the soft palate (superior PC), tip of the epiglottis (middle PC), and corniculate tubercle (inferior PC). In general, the three PC muscles exhibited similar patterns of activation. The PCs were activated during swallows, repetitive "pa" sounds, changes in head position, and the last portions of slow inspiratory and expiratory vital capacity maneuvers. Respiratory-related PC activity was infrequent during quiet breathing during wakefulness; variable and inconsistent phasic activation in expiration in one or more of the PCs was present in seven of the 10 subjects, particularly after a swallow. Progressive hyperoxic hypercapnia and progressive isocapnic hypoxia were associated with recruitment of phasic PC activity, which was predominantly expiratory; however, variable discharge patterns were observed within a given muscle and a given subject. When phasic PC activity was present, preactivation during late inspiration was frequently observed. PC activity was absent in NREM sleep and exhibited sporadic, nonrespiratory-related bursts of activity during REM sleep. Passively induced hypocapnic hyperventilation in NREM sleep was not associated with PC activation. The results indicate that the PCs have very similar patterns of activation and exhibit phasic expiratory activity during relatively high ventilatory output states in wakefulness.