A seven days course of eflornithine for relapsing Trypanosoma brucei gambiense sleeping sickness

Forty-seven patients with a relapse following a first treatment of Trypanosoma brucei gambiense trypanosomiasis were treated with a 7 d course of intravenous eflornithine (100 mg/kg every 6 h) and followed for 2 years. Four patients died after treatment, 2 of them possibly due to trypanosomiasis. On...

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Bibliographic Details
Published in:Transactions of the Royal Society of Tropical Medicine and Hygiene 1997-03, Vol.91 (2), p.212-213
Main Authors: Khonde, N., Pépin, J., Mpia, B.
Format: Article
Language:English
Subjects:
Adolescent
Adult
African trypanosomiasis
Aged
Animals
Antibiotics. Antiinfectious agents. Antiparasitic agents
Antiparasitic agents
Biological and medical sciences
chemotherapy
Child
Child, Preschool
Drug Administration Schedule
eflornithine
Eflornithine - administration & dosage
Eflornithine - therapeutic use
Female
Follow-Up Studies
Human protozoal diseases
Humans
Infant
Infant, Newborn
Infectious diseases
Male
Medical sciences
melarsoprol
Middle Aged
Parasitic diseases
Pharmacology. Drug treatments
Protozoal diseases
Recurrence
Treatment Failure
Tropical medicine
Trypanocidal Agents - administration & dosage
Trypanocidal Agents - therapeutic use
Trypanosoma brucei gambiense
Trypanosomiasis
Trypanosomiasis, African - cerebrospinal fluid
Trypanosomiasis, African - drug therapy
Trypanosomiasis, African - parasitology
Zaire
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Summary:Forty-seven patients with a relapse following a first treatment of Trypanosoma brucei gambiense trypanosomiasis were treated with a 7 d course of intravenous eflornithine (100 mg/kg every 6 h) and followed for 2 years. Four patients died after treatment, 2 of them possibly due to trypanosomiasis. One patient was completely lost to follow-up, 36 were followed for at least one year, and 25 have completed the 2 years' follow-up. Only one patient, a 5 years old child, subsequently relapsed. Considering this child and 2 of the fatalities as treatment failures, the rate of failure was 6·5%. A 7 d course of intravenous eflornithine is an adequate treatment for cases of Gambian trypanosomiasis relapsing after treatment with another drug.
ISSN:0035-9203
1878-3503
DOI:10.1016/S0035-9203(97)90228-5