Effects of fluoxetine on the immunosuppressive response to stress in mice

Mice exposed to a chronic auditory Stressor and treated with fluoxetine (5 mg/kg) showed a reduction in stress-induced suppression of thymus and spleen cellularity, and in peripheral T lymphocyte population. The blastogenic response of spleen lymphoid cells and the delayed type hypersensitivity resp...

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Bibliographic Details
Published in:Life sciences (1973) 1997, Vol.60 (26), p.PL403-PL413
Main Authors: Freire-Garabal, Manuel, Núñez, María J., Losada, Concepción, Pereiro, Dolores, Riveiro, María P., González-Patiño, Ezequiel, Mayán, JoséM., Rey-Méndez, Manuel
Format: Article
Language:English
Subjects:
Animals
blastogenic response
Cell Count - drug effects
delayed-type hypersensitivity
Female
fluoxetine
Fluoxetine - pharmacology
immunity
Immunosuppression
Mice
Mice, Inbred BALB C
Mice, Inbred C57BL
Spleen - drug effects
stress
Stress, Physiological - drug therapy
T-lymphocytes
T-Lymphocytes - drug effects
Thymus Gland - drug effects
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Summary:Mice exposed to a chronic auditory Stressor and treated with fluoxetine (5 mg/kg) showed a reduction in stress-induced suppression of thymus and spleen cellularity, and in peripheral T lymphocyte population. The blastogenic response of spleen lymphoid cells and the delayed type hypersensitivity response (DTH) to sheep red blood cells (SRBC) were also assessed and fluoxetine was found to partially reverse the inhibitory effect of stress on both parameters.
ISSN:0024-3205
1879-0631
DOI:10.1016/S0024-3205(97)00329-9