Leukotriene E4 plasma levels in adult asthmatic patients with variable disease severity

Cysteinyl leukotrienes (C-LTs) are local inflammatory mediators involved in bronchial asthma. Seventeen asthmatic patients (FEV1 ranging from 41 to 99.8% of predicted values) and 11 healthy subjects were studied. The clinical severity of asthma was assessed by the Aas score. Plasma C-LTs were measur...

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Bibliographic Details
Published in:Allergy (Copenhagen) 1997-05, Vol.52 (5), p.589-592
Main Authors: CHAVIS, C, VAN VYVE, T, CHANEZ, P, FARCE, M, BOUSQUET, J, MICHEL, F. B, GODARD, P
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
Asthma - blood
Asthma - diagnosis
Asthma - immunology
Biological and medical sciences
Biomarkers
Chronic obstructive pulmonary disease, asthma
Humans
Immunoenzyme Techniques
Leukotriene C4 - analysis
Leukotriene C4 - isolation & purification
Leukotriene E4 - analysis
Leukotriene E4 - blood
Leukotriene E4 - isolation & purification
Leukotrienes - analysis
Leukotrienes - isolation & purification
Medical sciences
Middle Aged
Pneumology
Severity of Illness Index
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Summary:Cysteinyl leukotrienes (C-LTs) are local inflammatory mediators involved in bronchial asthma. Seventeen asthmatic patients (FEV1 ranging from 41 to 99.8% of predicted values) and 11 healthy subjects were studied. The clinical severity of asthma was assessed by the Aas score. Plasma C-LTs were measured by enzyme immunoassay (EIA) after sample purification by solid-phase extraction (SPE), to investigate whether differences may exist between asthmatic and control subjects and whether leukotriene E4 (LTE4) levels were related to the severity of disease. LT measurements showed that 87.6 +/- 1.2% was recovered as LTE4 and 9.4 +/- 1.3% as LTC4. In asthmatic subjects, LTE4 plasma levels were found to be significantly higher than those in the control group (1.073 +/- 0.133 and 0.53 +/- 0.19 ng/ml of plasma, respectively; P < 0.002). Moreover, there was a significant correlation between LTE4 plasma levels and the Aas clinical score (P < 0.005). These data suggest that plasma LTE4 levels might be used to assess the severity of asthma.
ISSN:0105-4538
1398-9995
DOI:10.1111/j.1398-9995.1997.tb02606.x