CLINICAL EFFECTIVENESS OF CEFOPERAZONE FOR RESPIRATORY INFECTIONS OF ELDERLY PATIENTS, FOCUSING ON ITS SAFETY ON RENAL FUNCTION

• Published in: Japanese journal of antibiotics 1989/05/25, Vol.42(5), pp.1199-1207
• Main Authors: TANIMOTO, HIROICHI, SUZUKI, TOSHIMITSU, SATO, TAKEKI, HIROTA, YOSHIYUKI, NAGAI, HIDEAKI, YONEDA, RYOZO, MATSUDA, YOSHIHIKO, MOROZUMI, KATSUROU, KOHNO, NORIHIRO, KURIYAMA, TAKAYUKI, NAKAZAWA, HIROAKI, FUJIEDA, KAZUO, MORINARI, HAJIME, KATO, AKIHIKO, FUKAYAMA, MAKIKO, INAMATSU, TAKASHI, NAKADA, KOICHIRO, NAKAMORI, YOSHITAKA, HARA, SHIGEKO, ORITSU, MASARU, IKEDA, HIROTADA, OKUBO, TAKAO
• Format: Article
• Language: Japanese
• Subjects: Age Factors; Aged; Aged, 80 and over; Bilirubin - blood; Cefoperazone - pharmacokinetics; Cefoperazone - pharmacology; Cefoperazone - therapeutic use; Clinical Trials as Topic; Creatinine - blood; Female; Humans; Kidney - drug effects; Male; Middle Aged; Respiratory Tract Infections - drug therapy; Respiratory Tract Infections - physiopathology
• ISSN: 0368-2781; 2186-5477
• DOI: 10.11553/antibiotics1968b.42.1199

Clinical effectiveness of cefoperazone (CPZ) was studied for 46 elderly patients with respiratory infections. 1. Clinical efficacy rate of CPZ was 80.6% (29/36). 2. Adverse reactions occurred in 2 patients as systemic rush and fever. Laboratoryabnormalities were observed in 5 patients. These included elevation of transaminase value. 3. The serum concentration of CPZ at 12 hours after administration of 2 g CPZ was not reflected in creatinine clearance and total bilirubin, and those 2 values appearedto have little effects on CPZ excretion. 4. The administration of CPZ at 4g/day for less than 3 weeks had no effects on therenal function. As a result of this study, CPZ was found to have little undesirable effect on renal functions and to be a useful drug for the treatment of respiratory infections in elderly patients.