Singlet oxygen producing photosensitizers in photophoresis

In this study, the immunosuppressive properties of two photosensitizers (benzoporphyrin derivative monoacid ring A (BPD) and Photofrin® (HPD)), used for the photodynamic therapy of cancer, were investigated. The investigations were performed in our rat model for photophoresis. The validity of this m...

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Bibliographic Details
Published in:Journal of photochemistry and photobiology. B, Biology Biology, 1997-04, Vol.38 (2), p.203-208
Main Authors: van Iperen, H.Peter, Beijersbergen van Henegouwen, Gerard M.J.
Format: Article
Language:English
Subjects:
8-Methoxypsoralen
Animals
Antibody Formation - drug effects
Bacteriochlorin α
Benzoporphyrin derivative
Contact hypersensitivity
Delayed-type hypersensitivity
Dermatitis, Contact - etiology
Dermatitis, Contact - immunology
Dinitrofluorobenzene - pharmacology
Extracorporeal photochemotherapy
Hematoporphyrin Derivative - immunology
Hematoporphyrin Derivative - metabolism
Immunosuppressive Agents - immunology
Immunosuppressive Agents - metabolism
Male
Oxygen - metabolism
Photofrin
Photoimmunology
Photopheresis
Photophoresis
Photosensitizing Agents - immunology
Photosensitizing Agents - metabolism
Picryl Chloride - pharmacology
Porphyrins - immunology
Porphyrins - metabolism
Rats
Rats, Wistar
Singlet Oxygen
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Summary:In this study, the immunosuppressive properties of two photosensitizers (benzoporphyrin derivative monoacid ring A (BPD) and Photofrin® (HPD)), used for the photodynamic therapy of cancer, were investigated. The investigations were performed in our rat model for photophoresis. The validity of this model has been amply demonstrated. It enables a distinction to be made between antigen-specific and antigen non-specific immune suppression. With this model, the immune response which can be specifically suppressed is the contact hypersensitivity (CHS). CHS is induced by 2,4-dinitrofluorobenzene (DNFB). Both BPD and HPD are able to suppress CHS induced by DNFB. Furthermore, this generated suppression is transferable by the spleen cells of treated animals and is antigen non-specific.
ISSN:1011-1344
1873-2682
DOI:10.1016/S1011-1344(96)07442-8