Systemic mastocytosis following a malignant ovarian germ cell tumour

Cases of mediastinal germ cell tumours associated with haematological disorders (two cases of systemic mastocytosis included) have been reported previously. This combination is more frequent than would be expected by chance alone. We report the case of a 30‐year‐old woman, who presented with a syste...

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Bibliographic Details
Published in:Histopathology 1997-06, Vol.30 (6), p.582-584
Main Authors: DELACRÉTAZ, F., STALDER, M., MEUGÉ-MORAW, C., SCHMIDT, P.M., JORIS, F., KURT, A.-M., DE WERRA, P.
Format: Article
Language:English
Subjects:
Adolescent
Biological and medical sciences
Biopsy
bone marrow biopsy
Fatal Outcome
Female
Female genital diseases
Femur - diagnostic imaging
Fibrous Dysplasia, Polyostotic - diagnostic imaging
germ cell tumour
Germinoma - complications
Gynecology. Andrology. Obstetrics
haematological malignancies
Humans
mast cell
Mastocytosis - complications
Mastocytosis - diagnosis
Mastocytosis - pathology
Medical sciences
Ovarian Neoplasms - complications
ovarian tumour
Radiography
Spleen - pathology
Spleen - surgery
systemic mastocytosis
Tumors
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Summary:Cases of mediastinal germ cell tumours associated with haematological disorders (two cases of systemic mastocytosis included) have been reported previously. This combination is more frequent than would be expected by chance alone. We report the case of a 30‐year‐old woman, who presented with a systemic mastocytosis following a malignant ovarian germ cell tumour which was treated by chemo‐ and radiotherapy. The patient predominantly complained of skeletal pains, which led to an erroneous radiological diagnosis of fibrous dysplasia for years. An aggressive variant of systemic mastocytosis was diagnosed on bone marrow examination. Systemic mastocytosis was confirmed by splenectomy, liver biopsy and finally autopsy. The present case is unique because of the ovarian location of the germ cell tumour. We suggest our observation could be related to the broad group of haematological malignancies associated with germ cell tumours.
ISSN:0309-0167
1365-2559
DOI:10.1046/j.1365-2559.1997.5690793.x