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Genetic variation among strains of wild-type yellow fever virus from Senegal
H Wang, AD Jennings, KD Ryman, CM Late, E Wang, H Ni, PD Minor and AD Barrett Center for Tropical Diseases, University of Texas Medical Branch, Galveston 77555-0605, USA. We have examined and compared at the molecular level three strains of wild-type yellow fever (YF) virus isolated from Senegal in...
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| Published in: | Journal of general virology 1997-06, Vol.78 (6), p.1349-1352 |
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| Main Authors: | , , , , , , , |
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| Language: | English |
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| container_end_page | 1352 |
| container_issue | 6 |
| container_start_page | 1349 |
| container_title | Journal of general virology |
| container_volume | 78 |
| creator | Wang, H Jennings, AD Ryman, KD Late, CM Wang, E Ni, H Minor, PD Barrett, AD |
| description | H Wang, AD Jennings, KD Ryman, CM Late, E Wang, H Ni, PD Minor and AD Barrett
Center for Tropical Diseases, University of Texas Medical Branch, Galveston 77555-0605, USA.
We have examined and compared at the molecular level three strains of
wild-type yellow fever (YF) virus isolated from Senegal in 1927, 1953 and
1965, termed French viscerotropic virus, Rendu and Dak1279 respectively.
Over the structural protein genes, Rendu differed from the other two
strains by 8% at the nucleotide level. Rendu also differed antigenically,
possessing a 'vaccine'-specific envelope (E) protein epitope (i.e. an
epitope previously shown to be found on 17D and French neurotropic vaccine
viruses only and not wild-type strains of YF virus). Consequently, we
propose that at least two distinct genotypes of wild-type YF virus have
been present in Senegal. Since Rendu virus was isolated from a fatal case
of YF, it would indicate that the vaccine-specific epitope on the E protein
is not associated with attenuation of the viscerotropism of wild-type YF
virus. |
| doi_str_mv | 10.1099/0022-1317-78-6-1349 |
| format | article |
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Center for Tropical Diseases, University of Texas Medical Branch, Galveston 77555-0605, USA.
We have examined and compared at the molecular level three strains of
wild-type yellow fever (YF) virus isolated from Senegal in 1927, 1953 and
1965, termed French viscerotropic virus, Rendu and Dak1279 respectively.
Over the structural protein genes, Rendu differed from the other two
strains by 8% at the nucleotide level. Rendu also differed antigenically,
possessing a 'vaccine'-specific envelope (E) protein epitope (i.e. an
epitope previously shown to be found on 17D and French neurotropic vaccine
viruses only and not wild-type strains of YF virus). Consequently, we
propose that at least two distinct genotypes of wild-type YF virus have
been present in Senegal. Since Rendu virus was isolated from a fatal case
of YF, it would indicate that the vaccine-specific epitope on the E protein
is not associated with attenuation of the viscerotropism of wild-type YF
virus.</description><identifier>ISSN: 0022-1317</identifier><identifier>EISSN: 1465-2099</identifier><identifier>DOI: 10.1099/0022-1317-78-6-1349</identifier><identifier>PMID: 9191928</identifier><language>eng</language><publisher>England: Soc General Microbiol</publisher><subject>Genotype ; Senegal ; Viral Structural Proteins - genetics ; Yellow fever virus - genetics</subject><ispartof>Journal of general virology, 1997-06, Vol.78 (6), p.1349-1352</ispartof><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c409t-1c6dd5a8be16182986997f9432c6c5a5ea4e7ad891b15c63fb12c38a1b297ee73</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9191928$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wang, H</creatorcontrib><creatorcontrib>Jennings, AD</creatorcontrib><creatorcontrib>Ryman, KD</creatorcontrib><creatorcontrib>Late, CM</creatorcontrib><creatorcontrib>Wang, E</creatorcontrib><creatorcontrib>Ni, H</creatorcontrib><creatorcontrib>Minor, PD</creatorcontrib><creatorcontrib>Barrett, AD</creatorcontrib><title>Genetic variation among strains of wild-type yellow fever virus from Senegal</title><title>Journal of general virology</title><addtitle>J Gen Virol</addtitle><description>H Wang, AD Jennings, KD Ryman, CM Late, E Wang, H Ni, PD Minor and AD Barrett
Center for Tropical Diseases, University of Texas Medical Branch, Galveston 77555-0605, USA.
We have examined and compared at the molecular level three strains of
wild-type yellow fever (YF) virus isolated from Senegal in 1927, 1953 and
1965, termed French viscerotropic virus, Rendu and Dak1279 respectively.
Over the structural protein genes, Rendu differed from the other two
strains by 8% at the nucleotide level. Rendu also differed antigenically,
possessing a 'vaccine'-specific envelope (E) protein epitope (i.e. an
epitope previously shown to be found on 17D and French neurotropic vaccine
viruses only and not wild-type strains of YF virus). Consequently, we
propose that at least two distinct genotypes of wild-type YF virus have
been present in Senegal. Since Rendu virus was isolated from a fatal case
of YF, it would indicate that the vaccine-specific epitope on the E protein
is not associated with attenuation of the viscerotropism of wild-type YF
virus.</description><subject>Genotype</subject><subject>Senegal</subject><subject>Viral Structural Proteins - genetics</subject><subject>Yellow fever virus - genetics</subject><issn>0022-1317</issn><issn>1465-2099</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1997</creationdate><recordtype>article</recordtype><recordid>eNqFkE9LxDAQxYMouv75BCLkJF6qmbRNmqOIrsKCB_Uc0nS6RtpmTbq77Lc3yy56lDnMwHvzZvgRcgnsFphSd4xxnkEOMpNVJtJUqAMygUKUGU_6IZn8Ok7IaYxfjEFRlPKYHCtIxasJmU1xwNFZujLBmdH5gZreD3Max2DcEKlv6dp1TTZuFkg32HV-TVtcYaArF5aRtsH39C2FzE13To5a00W82Pcz8vH0-P7wnM1epy8P97PMFkyNGVjRNKWpagQBFVeVUEq2qsi5FbY0JZoCpWkqBTWUVuRtDdzmlYGaK4ko8zNyvctdBP-9xDjq3kWbfjMD-mXUUjEFJRf_GkHwkslcJWO-M9rgYwzY6kVwvQkbDUxvYestSr1FqWWlhd7CTltX-_hl3WPzu7Onm_Sbnf7p5p9rF1DPcehdulE7rxO_v6gfroGIQw</recordid><startdate>19970601</startdate><enddate>19970601</enddate><creator>Wang, H</creator><creator>Jennings, AD</creator><creator>Ryman, KD</creator><creator>Late, CM</creator><creator>Wang, E</creator><creator>Ni, H</creator><creator>Minor, PD</creator><creator>Barrett, AD</creator><general>Soc General Microbiol</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7U9</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>19970601</creationdate><title>Genetic variation among strains of wild-type yellow fever virus from Senegal</title><author>Wang, H ; Jennings, AD ; Ryman, KD ; Late, CM ; Wang, E ; Ni, H ; Minor, PD ; Barrett, AD</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c409t-1c6dd5a8be16182986997f9432c6c5a5ea4e7ad891b15c63fb12c38a1b297ee73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1997</creationdate><topic>Genotype</topic><topic>Senegal</topic><topic>Viral Structural Proteins - genetics</topic><topic>Yellow fever virus - genetics</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wang, H</creatorcontrib><creatorcontrib>Jennings, AD</creatorcontrib><creatorcontrib>Ryman, KD</creatorcontrib><creatorcontrib>Late, CM</creatorcontrib><creatorcontrib>Wang, E</creatorcontrib><creatorcontrib>Ni, H</creatorcontrib><creatorcontrib>Minor, PD</creatorcontrib><creatorcontrib>Barrett, AD</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of general virology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wang, H</au><au>Jennings, AD</au><au>Ryman, KD</au><au>Late, CM</au><au>Wang, E</au><au>Ni, H</au><au>Minor, PD</au><au>Barrett, AD</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Genetic variation among strains of wild-type yellow fever virus from Senegal</atitle><jtitle>Journal of general virology</jtitle><addtitle>J Gen Virol</addtitle><date>1997-06-01</date><risdate>1997</risdate><volume>78</volume><issue>6</issue><spage>1349</spage><epage>1352</epage><pages>1349-1352</pages><issn>0022-1317</issn><eissn>1465-2099</eissn><abstract>H Wang, AD Jennings, KD Ryman, CM Late, E Wang, H Ni, PD Minor and AD Barrett
Center for Tropical Diseases, University of Texas Medical Branch, Galveston 77555-0605, USA.
We have examined and compared at the molecular level three strains of
wild-type yellow fever (YF) virus isolated from Senegal in 1927, 1953 and
1965, termed French viscerotropic virus, Rendu and Dak1279 respectively.
Over the structural protein genes, Rendu differed from the other two
strains by 8% at the nucleotide level. Rendu also differed antigenically,
possessing a 'vaccine'-specific envelope (E) protein epitope (i.e. an
epitope previously shown to be found on 17D and French neurotropic vaccine
viruses only and not wild-type strains of YF virus). Consequently, we
propose that at least two distinct genotypes of wild-type YF virus have
been present in Senegal. Since Rendu virus was isolated from a fatal case
of YF, it would indicate that the vaccine-specific epitope on the E protein
is not associated with attenuation of the viscerotropism of wild-type YF
virus.</abstract><cop>England</cop><pub>Soc General Microbiol</pub><pmid>9191928</pmid><doi>10.1099/0022-1317-78-6-1349</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
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| ispartof | Journal of general virology, 1997-06, Vol.78 (6), p.1349-1352 |
| issn | 0022-1317 1465-2099 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_79091526 |
| source | Freely Accessible Science Journals - check A-Z of ejournals |
| subjects | Genotype Senegal Viral Structural Proteins - genetics Yellow fever virus - genetics |
| title | Genetic variation among strains of wild-type yellow fever virus from Senegal |
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