Relation of pacing-induced coronary resistance vessel dilation to total serum cholesterol and heart rate-blood pressure product

Coronary risk factors adversely affect coronary resistance vessel dilation to acetylcholine, but little is known about the effect of risk factors on coronary blood flow (CBF) responses to physiologic stimuli. CBF was derived from Doppler flow velocity (0.018-inch Doppler wire) and coronary diameter...

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Bibliographic Details
Published in:The American journal of cardiology 1997-07, Vol.80 (1), p.16-20
Main Authors: Anderson, Todd J., Goodhart, David M., Traboulsi, Mouhiedin, Knudtson, Merril L.
Format: Article
Language:English
Subjects:
Adenosine - pharmacology
Adult
Aged
Biological and medical sciences
Blood pressure
Blood Pressure - physiology
Cardiac Pacing, Artificial
Cardiology. Vascular system
Cardiovascular disease
Cholesterol
Cholesterol - blood
Coronary Angiography
Coronary Circulation - drug effects
Coronary Circulation - physiology
Coronary Disease - physiopathology
Coronary heart disease
Coronary vessels
Female
Heart
Heart Rate - physiology
Humans
Hypercholesterolemia - physiopathology
Male
Medical research
Medical sciences
Middle Aged
Prospective Studies
Regression Analysis
Risk Factors
Vascular Resistance - physiology
Vasodilation - physiology
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Summary:Coronary risk factors adversely affect coronary resistance vessel dilation to acetylcholine, but little is known about the effect of risk factors on coronary blood flow (CBF) responses to physiologic stimuli. CBF was derived from Doppler flow velocity (0.018-inch Doppler wire) and coronary diameter (quantitative angiography) in response to rapid atrial pacing in 50 patients (mean age 52 ± 12 years). Patients were prospectively divided into 3 groups based on their angiograms: group 1 (n = 17), normal coronary arteries; group 2 (n = 18), 1-vessel coronary artery disease (CAD) with a smooth study artery; group 3 (n = 15), 1-vessel CAD and an irregular study artery (
ISSN:0002-9149
1879-1913
DOI:10.1016/S0002-9149(97)00276-2