Higher prevalence of Borna disease virus infection in blood donors living near thoroughbred horse farms

It is believed that Borna disease virus (BDV), an etiological agent of progressive polioencephalomyelitis in horses and sheep, is closely associated with psychiatric disorders in humans since the prevalence of BDV is higher in psychiatric patients than in blood donors. We investigated whether or not...

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Bibliographic Details
Published in:Journal of medical virology 1997-07, Vol.52 (3), p.330-335
Main Authors: Takahashi, Hirokazu, Nakaya, Takaaki, Nakamura, Yurie, Asahi, Sayumi, Onishi, Yoshiko, Ikebuchi, Kenji, Takahashi, Tsuneo A., Katoh, Toshiaki, Sekiguchi, Sadayoshi, Takazawa, Masayuki, Tanaka, Hidetoshi, Ikuta, Kazuyoshi
Format: Article
Language:English
Subjects:
Animals
Animals, Domestic
Antibodies, Viral - blood
Base Sequence
Biological and medical sciences
blood donor
Blood Donors
Borna Disease - blood
Borna Disease - epidemiology
Borna Disease - immunology
Borna Disease - virology
Borna disease virus
Cell Line
DNA, Viral
Dogs
Epidemiology
Female
Fundamental and applied biological sciences. Psychology
horizontal transmission
horse
Horses
Male
Microbiology
Molecular Sequence Data
peripheral blood mononuclear cells
Prevalence
RT-PCR
Viral Proteins - immunology
Virology
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Summary:It is believed that Borna disease virus (BDV), an etiological agent of progressive polioencephalomyelitis in horses and sheep, is closely associated with psychiatric disorders in humans since the prevalence of BDV is higher in psychiatric patients than in blood donors. We investigated whether or not BDVs in humans are derived from infected domestic animals, by characterizing the BDVs in blood donors and horses derived from the same region of Hokkaido island, Japan. The seroprevalences (2.6 to 14.8%) of BDV were significantly higher in the blood donors from four regions where most horse farms are concentrated, compared with only 1% in the blood donors from Sapporo, the largest city in Hokkaido. BDV RNA was also detected in peripheral blood mononuclear cells from most of the seropositive horses and blood donors by nested reverse transcriptase‐polymerase chain reaction. These findings support that BDV may be horizontally transmitted, at least in part, from infected horses to humans. J. Med. Virol. 52:330–335, 1997. © 1997 Wiley‐Liss, Inc.
ISSN:0146-6615
1096-9071
DOI:10.1002/(SICI)1096-9071(199707)52:3<330::AID-JMV16>3.0.CO;2-M