Epigenetic approaches to developmental psychopathology

We evaluate the usefulness of 11 key epigenetic concepts from the behavior genetic research paradigm for advancing the field of developmental psychopathology. Key assumptions, empirical examples, and caveats in interpreting results are presented. We emphasize the usefulness of incorporating both dim...

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Bibliographic Details
Published in:Development and psychopathology 1997-06, Vol.9 (2), p.365-387
Main Authors: GOLDSMITH, H. H., GOTTESMAN, I. I., LEMERY, K. S.
Format: Article
Language:English
Subjects:
Adolescent
Adult
Child
Child Behavior Disorders - genetics
Child Behavior Disorders - psychology
Child, Preschool
Diseases in Twins - genetics
Diseases in Twins - psychology
Humans
Mental Disorders - genetics
Mental Disorders - psychology
Personality Development
Phenotype
Risk Factors
Social Environment
Temperament
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Summary:We evaluate the usefulness of 11 key epigenetic concepts from the behavior genetic research paradigm for advancing the field of developmental psychopathology. Key assumptions, empirical examples, and caveats in interpreting results are presented. We emphasize the usefulness of incorporating both dimensional (e.g., temperament trait) and categorical (e.g., diagnosis) variables, environmental measures, direct behavioral assessments, and multiple, theoretically relevant occasions of study into classic twin and family studies. We highlight contemporary techniques for identifying specific chromosomal regions associated with behavioral patterns, and the importance of considering nonmendelizing genetic influences when discerning the panorama of genetic influences on behavior.
ISSN:0954-5794
1469-2198
DOI:10.1017/S0954579497002095