The evidence of oxidative stress in cardiac surgery and septic patients: A comparative study

In present study, lipid peroxidation products (thiobarbituric acid reactive substances (TBARS) and diene conjugates (DC)) and markers of blood antioxidant status (serum antioxidative capacity (AOC) and red blood cells glutathione (RBC-GSH)) were measured to compare the extent of oxidative stress in...

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Bibliographic Details
Published in:Clinica chimica acta 1997-06, Vol.262 (1), p.77-88
Main Authors: Starkopf, Joel, Tamme, Kadri, Zilmer, Mihkel, Talvik, Raul, Samarütel, Jüri
Format: Article
Language:English
Subjects:
Adult
Aged
Antioxidant capacity
Antioxidants - metabolism
Biomarkers - blood
Cardiac surgery
Cardiac Surgical Procedures - adverse effects
Cardiopulmonary bypass
Female
Glutathione
Glutathione - blood
Humans
Male
Malondialdehydes
Middle Aged
Oxidative Stress
Oxygen free radicals
Sepsis
Sepsis - blood
Sepsis - metabolism
Sepsis - surgery
Systemic inflammatory response syndrome
Thiobarbituric Acid Reactive Substances - metabolism
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Summary:In present study, lipid peroxidation products (thiobarbituric acid reactive substances (TBARS) and diene conjugates (DC)) and markers of blood antioxidant status (serum antioxidative capacity (AOC) and red blood cells glutathione (RBC-GSH)) were measured to compare the extent of oxidative stress in 12 cardiac surgery and 10 septic general surgery patients. In heart surgery, arterial TBARS were significantly increased 15 min after the start and 15 min after cessation of cardiopulmonary bypass, while AOC at these times was decreased. Eighteen hours after surgery all parameters, except antioxidative capacity, had returned to preoperative levels. In septic patients, the preoperative level of lipid peroxidation was significantly higher and antioxidative capacity lower than in heart surgery patients. Surgery had no influence on oxidative stress markers in this group of patients. Increase in lipid peroxidation and reduction in blood antioxidant capacity, induced either by sepsis or cardiopulmonary bypass, were of comparable extent.
ISSN:0009-8981
1873-3492
DOI:10.1016/S0009-8981(97)06540-6