Pyridazinodiazepines as a High-Affinity, P2−P3 Peptidomimetic Class of Interleukin-1β-Converting Enzyme Inhibitor

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Bibliographic Details
Published in:Journal of medicinal chemistry 1997-06, Vol.40 (13), p.1941-1946
Main Authors: Dolle, Roland E, Prasad, C. V. C, Prouty, Catherine P, Salvino, Joseph M, Awad, Mohamed M. A, Schmidt, Stanley J, Hoyer, Denton, Ross, Tina Morgan, Graybill, Todd L, Speier, Gary J, Uhl, Joanne, Helaszek, Carla T, Ator, Mark A
Format: Article
Language:English
Subjects:
Animals
Azepines - chemistry
Azepines - pharmacokinetics
Biological and medical sciences
Bones, joints and connective tissue. Antiinflammatory agents
Dogs
Drug Design
Enzyme Inhibitors - chemical synthesis
Enzyme Inhibitors - pharmacokinetics
Medical sciences
Metabolic Clearance Rate
Pharmacology. Drug treatments
Pyridazines - chemistry
Pyridazines - pharmacokinetics
Serpins - chemical synthesis
Serpins - pharmacokinetics
Viral Proteins
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ISSN:0022-2623
1520-4804
DOI:10.1021/jm9701637