Expression of epithelial cadherin and cavernous sinus invasion in human pituitary adenomas

Pituitary adenomas generally are regarded as benign tumors, although some invade the cavernous sinus and recur. We examined the epithelial cadherin (E-CD) expression in 30 pituitary adenomas (6 with cavernous sinus invasion and 24 without). Immunoreactivity of E-CD were found in all pituitary adenom...

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Bibliographic Details
Published in:Journal of neuro-oncology 1997-09, Vol.34 (2), p.105-109
Main Authors: KAWAMOTO, H, MIZOUE, T, ARITA, K, TOMINAGA, A, EGUCHI, K, KURISU, K
Format: Article
Language:English
Subjects:
Adenoma - diagnosis
Adenoma - pathology
Adenoma - surgery
Adrenocorticotropic Hormone - analysis
Adult
Aged
Biological and medical sciences
Cadherins - analysis
Cadherins - biosynthesis
Cavernous Sinus
E-cadherin
Endocrinopathies
Female
Follicle Stimulating Hormone - analysis
Hormone replacement therapy
Human Growth Hormone - analysis
Humans
Hypothalamus. Hypophysis. Epiphysis (diseases)
Immunohistochemistry
Immunoreactivity
Magnetic Resonance Imaging
Male
Medical sciences
Middle Aged
Neoplasm Invasiveness
Non tumoral diseases. Target tissue resistance. Benign neoplasms
Pituitary
Pituitary Neoplasms - diagnosis
Pituitary Neoplasms - pathology
Pituitary Neoplasms - surgery
Sinuses
Tumors
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Description
Summary:Pituitary adenomas generally are regarded as benign tumors, although some invade the cavernous sinus and recur. We examined the epithelial cadherin (E-CD) expression in 30 pituitary adenomas (6 with cavernous sinus invasion and 24 without). Immunoreactivity of E-CD were found in all pituitary adenomas but they were very various. The presence of an association between E-CD expression and cavernous sinus invasion was assessed. There were no significant differences in E-CD expression between invasive and noninvasive adenomas. These results suggest that E-CD expression is not associated with cavernous sinus invasion in pituitary adenomas.
ISSN:0167-594X
1573-7373
DOI:10.1023/A:1005709014239