On the involvement of a tonic dopamine D2-autoinhibition in the regulation of pulse-to-pulse-evoked dopamine release in the rat striatum in vivo

The dopamine overflow evoked by trains of electrical stimulation pulses applied to the ascending dopaminergic pathway was measured with continuous amperometry in the striatum of anesthetised rats. As previously observed in in vitro studies, a pulse by pulse analysis showed a fall in dopamine overflo...

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Bibliographic Details
Published in:Naunyn-Schmiedeberg's archives of pharmacology 1997-06, Vol.355 (6), p.716-719
Main Authors: Dugast, C, Brun, P, Sotty, F, Renaud, B, Suaud-Chagny, M F
Format: Article
Language:English
Subjects:
Animals
Corpus Striatum - metabolism
Corpus Striatum - ultrastructure
Dopamine - metabolism
Dopamine Antagonists - pharmacology
Electric Stimulation
Haloperidol - pharmacology
Male
Rats
Rats, Sprague-Dawley
Receptors, Dopamine D2 - physiology
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Summary:The dopamine overflow evoked by trains of electrical stimulation pulses applied to the ascending dopaminergic pathway was measured with continuous amperometry in the striatum of anesthetised rats. As previously observed in in vitro studies, a pulse by pulse analysis showed a fall in dopamine overflow evoked by pulses 2 to 6, compared to the response evoked by pulse 1. However, in contrast with in vitro findings, the present in vivo data showed that the dopamine receptor antagonist haloperidol i) completely reverses the fall in dopamine overflow between pulse 1 and subsequent pulses, ii) enhances the dopamine overflow elicited by pulse 1. These results suggest that in vivo, both basal and pulse-evoked dopamine overflow results in stimulation of dopamine D2-type autoreceptors and therefore in regulation of dopamine release.
ISSN:0028-1298
DOI:10.1007/PL00005004