Immunohistochemical localization of macrophage migration inhibitory factor (MIF) in tanycytes, subcommissural organ and choroid plexus in the rat brain

We investigated the immunohistochemical localization of the macrophage migration inhibitory factor (MIF) in the rat brain. In addition to epithelial ependymal cells lining the ventricular wall, tanycytes in the basomedial hypothalamus were heavily immunostained. The immunoreactive processes of tanyc...

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Bibliographic Details
Published in:Brain research 1997-05, Vol.758 (1), p.259-262
Main Authors: Nishibori, Masahiro, Nakaya, Naoki, Mori, Shuji, Saeki, Kiyomi
Format: Article
Language:English
Subjects:
Animals
Brain - metabolism
Choroid plexus
Choroid Plexus - metabolism
Ependyma
Hypothalamus - metabolism
Immunohistochemistry
Macrophage migration inhibitory factor
Macrophage Migration-Inhibitory Factors - metabolism
Male
Rats
Rats, Wistar
Subcommissural organ
Subcommissural Organ - metabolism
Tanycyte
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Summary:We investigated the immunohistochemical localization of the macrophage migration inhibitory factor (MIF) in the rat brain. In addition to epithelial ependymal cells lining the ventricular wall, tanycytes in the basomedial hypothalamus were heavily immunostained. The immunoreactive processes of tanycytes made contacts to sinusoidal capillaries and reached the pial surface forming an immuno-positive structure at the floor of the hypothalamus. Other immunoreactive cells contained the subcommissural organ in the roof of the third ventricle and the epithelial lamina of the choroid plexus. The localization of MIF in cells which have contact with cerebrospinal fluid and blood vessels suggests that MIF might play a role as a humoral factor in the brain.
ISSN:0006-8993
1872-6240
DOI:10.1016/S0006-8993(97)00342-9