Two New Lignans with Activity against Influenza Virus from the Medicinal Plant Rhinacanthus nasutus

Two new lignans, rhinacanthin E (1) and rhinacanthin F (2), were isolated from the aerial parts of the plant Rhinacanthus nasutus. Their structures were established by detailed spectroscopic analysis. These compounds show significant antiviral activity against influenza virus type A.

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Bibliographic Details
Published in:Journal of natural products (Washington, D.C.) D.C.), 1997-06, Vol.60 (6), p.635-637
Main Authors: Kernan, Michael R, Sendl, Anna, Chen, Jian Lu, Jolad, Shivinand D, Blanc, Phillipe, Murphy, James T, Stoddart, Cheryl A, Nanakorn, Weerachai, Balick, Michael J, Rozhon, Edward J
Format: Article
Language:English
Subjects:
ACANTHACEAE
Antineoplastic Agents, Phytogenic - chemistry
Antineoplastic Agents, Phytogenic - isolation & purification
Antineoplastic Agents, Phytogenic - pharmacology
ANTIVIRAL
ANTIVIRAL AGENTS
Antiviral Agents - chemistry
Antiviral Agents - isolation & purification
Antiviral Agents - pharmacology
Biological and medical sciences
CHEMICAL COMPOSITION
CHEMICAL STRUCTURE
COMPOSICION QUIMICA
COMPOSITION CHIMIQUE
DRUG PLANTS
Drug Screening Assays, Antitumor
ESPECTROMETRIA
ESTRUCTURA QUIMICA
FEUILLE
General pharmacology
HOJAS
Influenza A virus - drug effects
INFLUENZAVIRUS
INFLUENZAVIRUS A
LEAVES
Lignans - chemistry
Lignans - isolation & purification
Lignans - pharmacology
LIGNINAS
LIGNINE
LIGNINS
Magnetic Resonance Spectroscopy
Mass Spectrometry
Medical sciences
Pharmacognosy. Homeopathy. Health food
Pharmacology. Drug treatments
Plant Leaves - chemistry
PLANTAS MEDICINALES
PLANTE MEDICINALE
Plants, Medicinal - chemistry
RHINACANTHIN E
RHINACANTHIN F
SPECTRAL ANALYSIS
SPECTROMETRIE
SPECTROMETRY
Spectrophotometry, Ultraviolet
STEMS
STRUCTURE CHIMIQUE
TAILANDIA
TALLO
THAILAND
THAILANDE
TIGE
Viral Plaque Assay
VIRICIDAS
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Description
Summary:Two new lignans, rhinacanthin E (1) and rhinacanthin F (2), were isolated from the aerial parts of the plant Rhinacanthus nasutus. Their structures were established by detailed spectroscopic analysis. These compounds show significant antiviral activity against influenza virus type A.
ISSN:0163-3864
1520-6025
DOI:10.1021/np960613i