Cardiolipin-fluorescent (M1) antimitochondrial antibody and cholestatic hepatitis in secondary syphilis

A 27-year-old black male with secondary syphilis and cholestatic jaundice is presented. The liver biopsy was believed to be most consistent with large bile duct obstruction, but both the ultrasound and endoscopic retrograde cholangiography were normal. Prior to treatment with penicillin, his serum w...

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Bibliographic Details
Published in:Digestive diseases and sciences 1989-08, Vol.34 (8), p.1298-1302
Main Authors: COMER, G. M, SHANKER MUKHERJEE, SACHDEV, R. K, CLAIN, D. J
Format: Article
Language:English
Subjects:
Adult
Autoantibodies - analysis
Biological and medical sciences
Cardiolipins - immunology
Cholestasis - complications
Cholestasis - immunology
Cholestasis - pathology
Enzyme-Linked Immunosorbent Assay
Fluorescent Antibody Technique
General aspects
Hepatitis - complications
Hepatitis - immunology
Hepatitis - pathology
Human infectious diseases. Experimental studies and models
Humans
Infectious diseases
Male
Medical sciences
Mitochondria - immunology
Syphilis - complications
Syphilis - immunology
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Summary:A 27-year-old black male with secondary syphilis and cholestatic jaundice is presented. The liver biopsy was believed to be most consistent with large bile duct obstruction, but both the ultrasound and endoscopic retrograde cholangiography were normal. Prior to treatment with penicillin, his serum was positive for antimitochondrial antibody. After treatment, the antibody was no longer detectable and the jaundice gradually resolved. The patient's pretreatment serum was, after further analysis, found to be positive for the antibody to the M1 antimitochondrial antigen subtype, which is identical to cardiolipin, the antigen in both the VDRL and Wasserman tests. A review of hepatic involvement in secondary syphilis is presented.
ISSN:0163-2116
1573-2568
DOI:10.1007/BF01537283